Effect of low-level laser therapy on chemoradiotherapy-induced oral mucositis and salivary inflammatory mediators in head and neck cancer patients
Oton-Leite AF, Silva GB, Morais MO, Silva TA, Leles CR, Valadares MC, Pinezi JC, Batista AC, Mendonça EF
Lasers in surgery and medicine · 74 citations
How it was studied
- Design
- Randomized controlled trial (indexed by PubMed)
- Studied in
- People
- Main outcome
- Health markers and function
Who paid for it
- Funding
- Independent funding
- Government
- Conselho Nacional de Desenvolvimento Científico e Tecnológico
Based on 1 listed funder(s).
Publication
- Published
- 2015-03-30 · Lasers Surg Med · vol. 47 · issue 4 · pp. 296–305
- Publisher
- Wiley
- Cited
- 113 citations · more than 92% of similar papers · 3.3× the field average
- Impact
- Top 10% most cited in its field
- References
- 52 works
- Access
- Paywalled
- Research areas
- Oral health in cancer treatment · Salivary Gland Disorders and Functions · Laser Applications in Dentistry and Medicine
- Keywords
- Mucositis, Medicine, Low level laser therapy, Saliva, Head and neck cancer, Radiation therapy, Internal medicine, Gastroenterology, Cancer, Oncology, Laser therapy
- MeSH
- saliva, humans, carcinoma, squamous cell, head and neck neoplasms, stomatitis, epidermal growth factor, metalloproteases, vascular endothelial growth factor a, cytokines, severity of illness index, double-blind method, middle aged, female, male, chemoradiotherapy, low-level light therapy
9 authors
From BR
- Angélica Ferreira Oton‐LeiteUniversidade Federal de Goiás
- Geisa Badauy L. SilvaUniversidade Federal de Goiás
- Marília Oliveira MoraisUniversidade Federal de Goiás
- Tarcı́lia Aparecida SilvaUniversidade Federal de Minas Gerais
- Cláudio Rodrigues LelesUniversidade Federal de Goiás
- Marize Campos ValadaresUniversidade Federal de Goiás
Abstract
Background and objective
Oral mucositis (OM) is considered a painful and debilitating side effect in patients receiving head and neck cancer treatment. Low-level laser therapy (LLLT) proved to be effective to prevent and treat chemoradiotherapy-induced OM. The aim of this study was to evaluate the effect of LLLT in the severity of OM in patients with head and neck cancer and on the release of salivary inflammatory mediators. Clinical (score of OM severity) and biochemical parameters (concentration of inflammatory mediators, growth factors, and enzymes in saliva) were used.
Materials and methods
Thirty patients were randomized into two groups: control and laser. LLLT was performed three times a week in the laser group, while control group received sham irradiation. OM severity was assessed according to the World Health Organization (WHO) and National Cancer Institute (NCI) scales. Pro-inflammatory and anti-inflammatory cytokines (TNF-α, IL-6, IL-1β, IL-10, TGF-β), growth factors (EGF, FGF, VEGF), and metalloproteinases (MMP2/TIMP2, MMP9/TIMP2) concentrations were assessed using ELISA test. Saliva samples were collected on admission, and at the 7th, 21st, and 35th sessions of radiotherapy.
Results
The laser group showed a reduction in the severity of OM, which coursed with significantly diminished salivary concentration of EGF and VEGF in the 7th radiotherapy session and of IL-6 and FGF in the 35th. There was a trend for reduced levels of IL-1β, TNF-α, IL-10, TGF-β, MMP2/TIMP2, MMP9/TIMP2 in the laser group compared to the control, however, no statistically significant differences were found.
Conclusions
These findings demonstrated that LLLT was effective in reducing the severity of chemoradiotherapy-induced OM and was associated with the reduction of inflammation and repair.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
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