Withania somnifera (Ashwagandha) in neurobehavioural disorders induced by brain oxidative stress in rodents: a systematic review and meta-analysis
Durg S, Dhadde SB, Vandal R, Shivakumar BS, Charan CS
The Journal of pharmacy and pharmacology · 74 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Meta-analysis (indexed by PubMed)
- Studied in
- Animals
- Main outcome
- Health markers and function
Who paid for it
- Funding
- Funding not disclosed
Publication
- Published
- 2015-04-02 · J Pharm Pharmacol · vol. 67 · issue 7 · pp. 879–899
- Publisher
- Oxford University Press
- Cited
- 106 citations · more than 88% of similar papers · 2.2× the field average
- References
- 44 works
- Access
- Paywalled
- Research areas
- Phytochemicals and Medicinal Plants · Andrographolide Research and Applications · Medicinal Plants and Neuroprotection
- Keywords
- Withania somnifera, Oxidative stress, Superoxide dismutase, Glutathione peroxidase, Medicine, Lipid peroxidation, Neuroprotection, Pharmacology, Glutathione, Neuroscience, Biochemistry, Pathology, Internal medicine, Chemistry, Psychology, Enzyme
- MeSH
- brain, animals, humans, rodentia, withania, nervous system diseases, drugs, chinese herbal, oxidative stress
5 authors
From US, CY
- Sharanbasappa Durg · corresponding
- Shivsharan Basavraj Dhadde
- Ravichandra VandalGrace College & Seminary
- Badamaranahalli S Shivakumar
- C.S. CharanKES College
Abstract
Objectives
Withania somnifera has been in use for several thousand years in Ayurveda to treat various neurological disorders. There is, however, not much scientific data on its protective role in neuronal pathology specifically against brain oxidative stress. Hence, an attempt is made in this work for systematic review and meta-analysis of W. somnifera on neurobehavioural disorders induced by brain oxidative stress in rodents.
Methods
A systematic search of the effect of W. somnifera on brain oxidative stress-induced neuronal pathology was performed using electronic databases. The systematic review was performed on neurobehavioural parameters, whereas meta-analysis of W. somnifera effect was done on oxidative stress markers (superoxide dismutase, catalase, glutathione peroxidase, glutathione and lipid peroxidation), nitrite, protein carbonyl, AchE, ChAT and Ach of rodent brain. Data were analysed using Review Manager Software.
Key findings
Twenty-eight studies were selected based upon the inclusion and exclusion criteria. W. somnifera appreciably inhibited the neurological abnormalities due to oxidative stress in rodent brain produced by different physical and chemical stimuli. W. somnifera also significantly restored the altered oxidative and other stress markers in different parts of rodent brain.
Summary
The systematic review provides scientific evidence for the traditional claim of W. somnifera use in different neurological aliments. However, future clinical trials are mandated to establish the therapeutic efficacy and safety in human beings.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
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