Association of cholesterol with risk of pancreatic cancer: a meta-analysis
Wang J, Wang WJ, Zhai L, Zhang DF
World journal of gastroenterology · 48 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Meta-analysis (indexed by PubMed)
- Studied in
- People
- Main outcome
- Clinical events such as disease or death
- Intake measured by
- Not stated
Who paid for it
- Funding
- Funding not disclosed
Publication
- Published
- 2015-01-01 · World J Gastroenterol · vol. 21 · issue 12 · p. 3711
- Publisher
- Baishideng Publishing Group
- Cited
- 70 citations · more than 36% of similar papers · 0.2× the field average
- References
- 45 works
- Access
- Open access (hybrid journal) · CC-BY-NC
- Research areas
- Cancer, Lipids, and Metabolism · Pancreatic and Hepatic Oncology Research · Pancreatitis Pathology and Treatment
- Keywords
- Medicine, Meta-analysis, Pancreatic cancer, Internal medicine, Relative risk, Subgroup analysis, Confidence interval, Cohort study, Cholesterol, Cancer, Gastroenterology
- MeSH
- humans, pancreatic neoplasms, hypercholesterolemia, cholesterol, dietary, prognosis, odds ratio, risk assessment, risk factors, aged, middle aged, female, male
1 author
- Jia Hao Wang · corresponding
Abstract
Aim
To evaluate the effect of dietary cholesterol and serum total cholesterol (TC) on the risk of pancreatic cancer.
Methods
A literature search was performed up to June 2014 in PubMed, EMBASE, China National Knowledge Infrastructure and China Biology Medical literature database for relevant articles published in English or Chinese. Pooled relative risks (RRs) with 95% confidence intervals (CIs) were calculated with a random-effects model.
Results
We included 14 published articles with 439355 participants for dietary cholesterol, and 6 published articles with 1805697 participants for serum TC. For the highest vs lowest category of dietary cholesterol, the pooled RR (95%CI) of pancreatic cancer was 1.308 (1.097-1.559). After excluding two studies (RR > 3.0), the pooled RR (95%CI) was 1.204 (1.050-1.380). In subgroup analysis stratified by study design, the pooled RRs (95%CIs) were 1.523 (1.226-1.893) for case-control studies and 1.023 (0.871-1.200) for cohort studies. The association of dietary cholesterol with the risk of pancreatic cancer was significant for studies conducted in North America [1.275 (1.058-1.537)] and others [2.495 (1.565-3.977)], but not in Europe [1.149 (0.863-1.531)]. No significant association [1.003 (0.859-1.171)] was found between the risk of pancreatic cancer and serum TC.
Conclusion
Dietary cholesterol may be associated with an increased risk of pancreatic cancer in worldwide populations, except for Europeans. The results need to be confirmed further.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
Community trust
Loading…
How much do you trust this study's findings?
Comments
Sign in to rate, comment on or flag this study.Sign inSomething wrong here?
Flag this study if its information, labels or funding look wrong. An editor reviews every flag.
Sign in to rate, comment on or flag this study.Sign inEducational information about published research. Not medical advice, and not a recommendation to start or stop anything.