Funded in part by Seminis Vegetable Seeds Inc.
Diet rich in high glucoraphanin broccoli reduces plasma LDL cholesterol: Evidence from randomised controlled trials
Armah CN, Derdemezis C, Traka MH, Dainty JR, Doleman JF, Saha S, Leung W, Potter JF, Lovegrove JA, Mithen RF
Molecular nutrition & food research · 74 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Randomized controlled trial (indexed by PubMed)
- Studied in
- People
- Main outcome
- Health markers and function
- Intake measured by
- Food provided by researchers
Who paid for it
- Funding
- Industry funded
- Government
- Technology Strategy Board
- Government
- Biotechnology and Biological Sciences Research Council
- Company
- Seminis Vegetable Seeds Inc.
- Grants
- Technology Strategy Board (101119); Biotechnology and Biological Sciences Research Council (BBS/E/F/00044431); Biotechnology and Biological Sciences Research Council (BBS/E/F/00041700); Biotechnology and Biological Sciences Research Council (BBS/E/F/00044431); Biotechnology and Biological Sciences Research Council (BB/J004545/1)
Based on 3 listed funder(s).
Publication
- Published
- 2015-04-07 · Mol Nutr Food Res · vol. 59 · issue 5 · pp. 918–926
- Publisher
- Wiley
- Cited
- 106 citations · more than 92% of similar papers · 3.1× the field average
- Impact
- Top 10% most cited in its field
- References
- 53 works
- Access
- Open access (hybrid journal) · CC-BY
- Research areas
- Genomics, phytochemicals, and oxidative stress · Phytochemicals and Antioxidant Activities · Pharmacological Effects of Natural Compounds
- Keywords
- Glucoraphanin, Ldl cholesterol, Food science, Cholesterol, Chemistry, NAK, Internal medicine, Medicine, Biochemistry, Botany, Biology, Brassica
- MeSH
- humans, brassica, oximes, imidoesters, sulfoxides, glucosinolates, apolipoproteins e, diet, polymorphism, single nucleotide, aged, middle aged, female, male, pten phosphohydrolase, cholesterol, ldl, amp-activated protein kinases, phosphatidylinositol 3-kinases
10 authors
From US, GB
- Charlotte N. ArmahNorwich University; Quadram Institute
- Christos S. DerdemezisUniversity of Reading
- Μαρία ΤράκαNorwich University; Quadram Institute
- Jack R. DaintyNorwich University; Quadram Institute
- Joanne F. DolemanNorwich University; Quadram Institute
- Shikha SahaNorwich University; Quadram Institute
Abstract
Scope
Cruciferous-rich diets have been associated with reduction in plasma LDL-cholesterol (LDL-C), which may be due to the action of isothiocyanates derived from glucosinolates that accumulate in these vegetables. This study tests the hypothesis that a diet rich in high glucoraphanin (HG) broccoli will reduce plasma LDL-C.
Methods and results
One hundred and thirty volunteers were recruited to two independent double-blind, randomly allocated parallel dietary intervention studies, and were assigned to consume either 400 g standard broccoli or 400 g HG broccoli per week for 12 weeks. Plasma lipids were quantified before and after the intervention. In study 1 (37 volunteers), the HG broccoli diet reduced plasma LDL-C by 7.1% (95% CI: -1.8%, -12.3%, p = 0.011), whereas standard broccoli reduced LDL-C by 1.8% (95% CI +3.9%, -7.5%, ns). In study 2 (93 volunteers), the HG broccoli diet resulted in a reduction of 5.1% (95% CI: -2.1%, -8.1%, p = 0.001), whereas standard broccoli reduced LDL-C by 2.5% (95% CI: +0.8%, -5.7%, ns). When data from the two studies were combined the reduction in LDL-C by the HG broccoli was significantly greater than standard broccoli (p = 0.031).
Conclusion
Evidence from two independent human studies indicates that consumption of high glucoraphanin broccoli significantly reduces plasma LDL-C.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
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