Modulation of muscle metaboreceptor activation upon sweating and cutaneous vascular responses to rising core temperature in humans
Amano T, Ichinose M, Inoue Y, Nishiyasu T, Koga S, Kondo N
American journal of physiology. Regulatory, integrative and comparative physiology · 11 citations
How it was studied
- Design
- Controlled clinical trial (classified by our AI screen)
- Studied in
- People
- Main outcome
- Health markers and function
Who paid for it
- Funding
- Independent funding
- Government
- Japan Society for the Promotion of Science
- Government
- Japan Society for the Promotion of Science (JSPS)
- Grants
- Japan Society for the Promotion of Science (23300231); Japan Society for the Promotion of Science (23247046); Japan Society for the Promotion of Science (26882026)
Based on 2 listed funder(s).
Publication
- Published
- 2015-04-09 · Am J Physiol Regul Integr Comp Physiol · vol. 308 · issue 12 · pp. R990–R997
- Publisher
- American Physiological Society
- Cited
- 11 citations · more than 79% of similar papers · 1.3× the field average
- References
- 52 works
- Access
- Paywalled
- Research areas
- Thermoregulation and physiological responses · Infrared Thermography in Medicine · Heart Rate Variability and Autonomic Control
- Keywords
- Forearm, Isometric exercise, Thermoregulation, Vasodilation, Medicine, Core temperature, Perfusion, Peripheral, Core (optical fiber), Internal medicine, Stimulation, Endocrinology, Chemistry, Cardiology, Anesthesia, Anatomy, Materials science
- MeSH
- muscle, skeletal, skin, humans, ischemia, water, reflex, hand strength, immersion, signal transduction, body temperature regulation, sweating, regional blood flow, vasodilation, muscle contraction, time factors, female, male, hot temperature, sensory receptor cells, young adult
6 authors
From JP
- Tatsuro AmanoKobe University
- Masashi IchinoseMeiji University
- Yoshimitsu InoueOsaka International University
- Takeshi NishiyasuUniversity of Tsukuba
- Shunsaku KogaKobe Design University
- Narihiko Kondo · correspondingKobe University
Abstract
The present study investigated the role of muscle metaboreceptor activation on human thermoregulation by measuring core temperature thresholds and slopes for sweating and cutaneous vascular responses during passive heating associated with central and peripheral mechanisms. Six male and eight female subjects inserted their lower legs into hot water (43°C) while wearing a water perfusion suit on the upper body (34°C). One minute after immersion, an isometric handgrip exercise--40% of maximum voluntary contraction-was conducted for 1.5 min in both control and experimental conditions, while postexercise occlusion was performed in the experimental condition only for 9 min. The postexercise forearm occlusion during passive heating consistently stimulated muscle metaboreceptors, as implicated by significantly elevated mean arterial blood pressure throughout the experimental period (P <0.05). Stimulation of the forearm muscle metaboreceptors increased sweating and cutaneous vascular responses during passive heating, and was associated with significant reductions in esophageal temperature threshold of sweating and cutaneous vasodilation (Δ threshold, sweating: 0.33 ± 0.05 and 0.16 ± 0.04°C, cutaneous vascular conductance: 0.38 ± 0.08 and 0.16 ± 0.05°C for control and experimental groups, respectively, P < 0.05). The slopes of these responses were not different between the conditions. These results suggest that muscle metaboreceptor activation in the forearm accelerates sweating and cutaneous vasodilation during passive heating associated with a reduction in core temperature thresholds and may be related to central mechanisms controlling heat loss responses.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
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