Consumption of whole grains and cereal fiber and total and cause-specific mortality: prospective analysis of 367,442 individuals
Huang T, Xu M, Lee A, Cho S, Qi L
BMC medicine · 108 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Cohort study (indexed by PubMed)
- Studied in
- People
- Main outcome
- Clinical events such as disease or death
- Intake measured by
- Not stated
Who paid for it
- Funding
- Industry funded
- Government
- National Institutes of Health
- Government
- National Heart, Lung, and Blood Institute
- Government
- National Institute of Diabetes and Digestive and Kidney Diseases
- Government
- NIDDK NIH HHS
- Government
- NHLBI NIH HHS
- Authors
- At least one author declares a financial tie to industry
- Grants
- National Institute of Diabetes and Digestive and Kidney Diseases (P30DK046200); National Institute of Diabetes and Digestive and Kidney Diseases (DK091718); National Institute of Diabetes and Digestive and Kidney Diseases (R01 DK091718); National Heart, Lung, and Blood Institute (R01 HL071981); National Heart, Lung, and Blood Institute (HL-071981); National Institute of Diabetes and Digestive and Kidney Diseases (DK46200.)
Based on 5 listed funder(s) and full-text disclosure statement.
Publication
- Published
- 2015-03-23 · BMC Med · vol. 13 · issue 1 · p. 59
- Publisher
- BioMed Central
- Cited
- 182 citations · more than 100% of similar papers · 15.4× the field average
- Impact
- Top 10% most cited in its field
- References
- 35 works
- Access
- Open access (journal) · CC-BY
- Research areas
- Food composition and properties · Nutritional Studies and Diet · Phytoestrogen effects and research
- Keywords
- Medicine, Diabetes mellitus, Prospective cohort study, Cause of death, Disease, Whole grains, Stroke (engine), Mortality rate, Cancer, Internal medicine, Endocrinology, Food science
- MeSH
- humans, cardiovascular diseases, diet, diet surveys, proportional hazards models, prospective studies, dietary fiber, aged, middle aged, female, male, edible grain
5 authors
From US
- Tao HuangHarvard University
- Min XuHarvard University
- Albert LeeRoyal Oak Community Coalition
- Susan Cho
- Lu Qi · correspondingBrigham and Women's Hospital; Harvard University
Abstract
Background
Intakes of whole grains and cereal fiber have been inversely associated with the risk of chronic diseases; however, their relation with total and disease-specific mortality remain unclear. We aimed to prospectively assess the association of whole grains and cereal fiber intake with all causes and cause-specific mortality.
Methods
The study included 367,442 participants from the prospective NIH-AARP Diet and Health Study (enrolled in 1995 and followed through 2009). Participants with cancer, heart disease, stroke, diabetes, and self-reported end-stage renal disease at baseline were excluded.
Results
Over an average of 14 years of follow-up, a total of 46,067 deaths were documented. Consumption of whole grains were inversely associated with risk of all-cause mortality and death from cancer, cardiovascular disease (CVD), diabetes, respiratory disease, infections, and other causes. In multivariable models, as compared with individuals with the lowest intakes, those in the highest intake of whole grains had a 17% (95% CI, 14-19%) lower risk of all-cause mortality and 11-48% lower risk of disease-specific mortality (all P for trend <0.023); those in the highest intake of cereal fiber had a 19% (95% CI, 16-21%) lower risk of all-cause mortality and 15-34% lower risk of disease-specific mortality (all P for trend <0.005). When cereal fiber was further adjusted, the associations of whole grains with death from CVD, respiratory disease and infections became not significant; the associations with all-cause mortality and death from cancer and diabetes were attenuated but remained significant (P for trend <0.029).
Conclusions
Consumption of whole grains and cereal fiber was inversely associated with reduced total and cause-specific mortality. Our data suggest cereal fiber is one potentially protective component.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
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