Twenty-four-hour urine osmolality as a physiological index of adequate water intake
Perrier ET, Buendia-Jimenez I, Vecchio M, Armstrong LE, Tack I, Klein A
Disease markers · 90 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Cross-sectional study (classified by our AI screen)
- Studied in
- People
- Main outcome
- Health markers and function
Who paid for it
- Funding
- Independent funding
- Authors
- At least one author declares a financial tie to industry
Based on full-text disclosure statement.
Publication
- Published
- 2015-01-01 · Dis Markers · vol. 2015 · pp. 1–8
- Publisher
- Hindawi Publishing Corporation
- Cited
- 123 citations · more than 97% of similar papers · 6.4× the field average
- Impact
- Top 10% most cited in its field
- References
- 37 works
- Access
- Open access (hybrid journal) · CC-BY
- Research areas
- Electrolyte and hormonal disorders · Thermoregulation and physiological responses · Birth, Development, and Health
- Keywords
- Urine osmolality, Urine, Fluid intake, Urine specific gravity, Morning, Plasma osmolality, Vasopressin, Osmole, Medicine, Antidiuretic, Urinary system, Diuresis, Endocrinology, Physiology, Internal medicine, Renal function, Animal science, Biology
- MeSH
- urine, humans, urinalysis, water-electrolyte balance, drinking, osmolar concentration, adult, female, male, recommended dietary allowances
6 authors
From FR, US
- Erica T. Perrier · correspondingDanone (France)
- Inmaculada Buendia-JimenezDanone (France)
- Mariacristina VecchioDanone (France)
- Lawrence E. ArmstrongUniversity of Connecticut
- Ivan TackInserm; Hôpital Rangueil
- Alexis KleinDanone (France)
Abstract
While associations exist between water, hydration, and disease risk, research quantifying the dose-response effect of water on health is limited. Thus, the water intake necessary to maintain optimal hydration from a physiological and health standpoint remains unclear. The aim of this analysis was to derive a 24 h urine osmolality (U(Osm)) threshold that would provide an index of "optimal hydration," sufficient to compensate water losses and also be biologically significant relative to the risk of disease. Ninety-five adults (31.5 ± 4.3 years, 23.2 ± 2.7 kg·m(-2)) collected 24 h urine, provided morning blood samples, and completed food and fluid intake diaries over 3 consecutive weekdays. A U(Osm) threshold was derived using 3 approaches, taking into account European dietary reference values for water; total fluid intake, and urine volumes associated with reduced risk for lithiasis and chronic kidney disease and plasma vasopressin concentration. The aggregate of these approaches suggest that a 24 h urine osmolality ≤500 mOsm·kg(-1) may be a simple indicator of optimal hydration, representing a total daily fluid intake adequate to compensate for daily losses, ensure urinary output sufficient to reduce the risk of urolithiasis and renal function decline, and avoid elevated plasma vasopressin concentrations mediating the increased antidiuretic effort.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
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