Prospective study of breast cancer in relation to coffee, tea and caffeine in Sweden
Oh JK, Sandin S, Ström P, Löf M, Adami HO, Weiderpass E
International journal of cancer · 49 citations
How it was studied
- Design
- Cohort study (indexed by PubMed)
- Studied in
- People
- Main outcome
- Clinical events such as disease or death
Who paid for it
- Funding
- Independent funding
- Government
- Vetenskapsrådet
- Government
- Swedish Research Council
- Grants
- Vetenskapsrådet (K2012–69X-22062–01-3)
Based on 2 listed funder(s).
Publication
- Published
- 2015-04-17 · Int J Cancer · vol. 137 · issue 8 · pp. 1979–1989
- Publisher
- Wiley
- Cited
- 71 citations · more than 96% of similar papers · 6.1× the field average
- Impact
- Top 10% most cited in its field
- References
- 62 works
- Access
- Free to read
- Research areas
- Coffee research and impacts · Tea Polyphenols and Effects · Nutritional Studies and Diet
- Keywords
- Medicine, Caffeine, Breast cancer, Relative risk, Poisson regression, Confounding, Confidence interval, Prospective cohort study, Lower risk, Incidence (geometry), Cancer, Gynecology, Demography, Internal medicine, Environmental health, Population
- MeSH
- humans, breast neoplasms, caffeine, receptors, estrogen, receptors, progesterone, risk factors, regression analysis, follow-up studies, prospective studies, coffee, tea, adult, middle aged, sweden, female
6 authors
From SE, KR, US, NO, FI
- Jin‐Kyoung OhKarolinska Institutet; National Cancer Center
- Sven SandinKarolinska Institutet
- Peter C. StrømKarolinska Institutet
- Marie LöfKarolinska Institutet
- Hans‐Olov AdamiHarvard University; Karolinska Institutet
- Elisabete Weiderpass · correspondingKarolinska Institutet; Cancer Registry of Norway; Folkhälsans Forskningscentrum; UiT The Arctic University of Norway
Abstract
Studies of coffee and tea consumption and caffeine intake as risk factors for breast cancer are inconclusive. We assessed coffee and tea consumption, caffeine intake, and possible confounding factors among 42,099 women from the Swedish Women's Lifestyle and Health study, the participants of which were aged 30-49 years at enrollment in 1991-1992. Complete follow-up for breast cancer incidence was performed through 2012 via linkage to national registries. Poisson regression models were used to estimate relative risks (RRs) and 95% confidence intervals (CIs) for breast cancer. During follow-up 1,395 breast cancers were diagnosed. The RR was 0.97 (95% CI 0.94-0.99) for a 1-unit increase in cups of coffee/day, 1.14 (95% CI 1.05-1.24) for a 1-unit increase in cups of tea/day, and 0.97 (95% CI 0.95-1.00) for a 100 mg/day increase in caffeine intake. Although the RR for no consumption (RR = 0.86, 95% CI 0.69-1.08), a group with a relatively small number of women, was not statistically significant, women with higher consumption had a decreased breast cancer risk (3-4 cups/day: RR = 0.87, 95% CI 0.76-1.00; ≥5 cups/day: RR = 0.81, 95% CI 0.70-0.94) compared to women consuming 1-2 cups of coffee/day. Compared to no consumption, women consuming >1 cups tea/day showed an increased breast cancer risk (RR = 1.19, 95% CI 1.00-1.42). Similar patterns of estimates were observed for breast cancer risk overall, during pre- and postmenopausal years, and for ER+ or PR+ breast cancer, but not for ER- and PR- breast cancer. Our findings suggest that coffee consumption and caffeine intake is negatively associated with the risk of overall and ER+/PR- breast cancer, and tea consumption is positively associated with the risk of overall and ER+/PR+ breast cancer.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
Community trust
Loading…
How much do you trust this study's findings?
Comments
Sign in to rate, comment on or flag this study.Sign inSomething wrong here?
Flag this study if its information, labels or funding look wrong. An editor reviews every flag.
Sign in to rate, comment on or flag this study.Sign inEducational information about published research. Not medical advice, and not a recommendation to start or stop anything.