Efficacy and safety of creatine supplementation in juvenile dermatomyositis: A randomized, double-blind, placebo-controlled crossover trial
Solis MY, Hayashi AP, Artioli GG, Roschel H, Sapienza MT, Otaduy MC, De Sã Pinto AL, Silva CA, Sallum AM, Pereira RM, Gualano B
Muscle & nerve · 22 citations
How it was studied
- Design
- Randomized controlled trial (indexed by PubMed)
- Studied in
- People
- Main outcome
- Health markers and function
Who paid for it
- Funding
- Independent funding
- Nonprofit
- Federico and Elvia Faggin Foundation
- Government
- Conselho Nacional de Desenvolvimento Científico e Tecnológico
- Government
- Fundação do Amparo ̀ Pesquisa do Estado de São Paulo
- University or hospital
- Núcleo de Apoio à Pesquisa “Saúde da Criança e do Adolescente” da USP
- Government
- Coordenação de Aperfeiçoamento de Pessoal de Ensino Superior
- Nonprofit
- Federico Foundation
Based on 6 listed funder(s).
Publication
- Published
- 2015-04-21 · Muscle Nerve · vol. 53 · issue 1 · pp. 58–66
- Publisher
- Wiley
- Cited
- 37 citations · more than 82% of similar papers · 1.4× the field average
- References
- 48 works
- Access
- Paywalled
- Research areas
- Inflammatory Myopathies and Dermatomyositis · Muscle metabolism and nutrition · Muscle Physiology and Disorders
- Keywords
- Medicine, Creatine, Juvenile dermatomyositis, Crossover study, Creatine Monohydrate, Placebo, Adverse effect, Internal medicine, Creatine kinase, Dermatomyositis, Randomized controlled trial, Phosphocreatine, Physical therapy, Gastroenterology, Pathology
- MeSH
- muscle, skeletal, humans, dermatomyositis, creatine, phosphocreatine, cytokines, magnetic resonance imaging, exercise, magnetic resonance spectroscopy, sensitivity and specificity, cross-over studies, double-blind method, body composition, eating, bone density, quality of life, dietary supplements, adolescent, child, female, male, young adult, visual analog scale, surveys and questionnaires
11 authors
From BR
- Marina Yázigi SolisUniversidade de São Paulo
- Ana Paula HayashiUniversidade de São Paulo
- Guilherme Giannini ArtioliUniversidade de São Paulo
- Hamilton RoschelUniversidade de São Paulo
- Marcelo Tatit SapienzaUniversidade de São Paulo
- Maria Concepción García OtaduyUniversidade de São Paulo
Abstract
Introduction
It has been suggested that creatine supplementation is safe and effective for treating idiopathic inflammatory myopathies, but no pediatric study has been conducted to date. The objective of this study was to examine the efficacy and safety of creatine supplementation in juvenile dermatomyositis (JDM) patients.
Methods
In this study, JDM patients received placebo or creatine supplementation (0.1 g/kg/day) in a randomized, crossover, double-blind design. Subjects were assessed at baseline and after 12 weeks. The primary outcome was muscle function. Secondary outcomes included body composition, aerobic conditioning, health-related quality of life, and muscle phosphocreatine (PCr) content. Safety was assessed by laboratory parameters and kidney function measurements.
Results
Creatine supplementation did not affect muscle function, intramuscular PCr content, or any other secondary outcome. Kidney function was not affected, and no side effects were reported.
Conclusions
Twelve weeks of creatine supplementation in JDM patients were well-tolerated and free of adverse effects, but treatment did not affect muscle function, intramuscular PCr, or any other parameter.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
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