Funded in part by General Mills
Plasma alkylresorcinols, biomarkers of whole-grain intake, are not associated with progression of coronary artery atherosclerosis in postmenopausal women with coronary artery disease
McKeown NM, Hruby A, Landberg R, Herrington DM, Lichtenstein AH
Public health nutrition · 7 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Randomized controlled trial (indexed by PubMed)
- Studied in
- People
- Main outcome
- Health markers and function
- Intake measured by
- Food frequency questionnaire
Who paid for it
- Funding
- Industry funded
- Company
- General Mills
- University or hospital
- Tufts Medical Center
- Government
- National Heart, Lung, and Blood Institute
- Government
- NHLBI NIH HHS
- Grants
- National Heart, Lung, and Blood Institute (U01 HL 45488)
Based on 4 listed funder(s).
Publication
- Published
- 2015-04-23 · Public Health Nutr · vol. 19 · issue 2 · pp. 326–331
- Publisher
- Cambridge University Press
- Cited
- 10 citations · more than 78% of similar papers · 1.2× the field average
- References
- 39 works
- Access
- Free to read
- Research areas
- Food composition and properties · Bariatric Surgery and Outcomes · Phytoestrogen effects and research
- Keywords
- Medicine, Coronary artery disease, Internal medicine, Cardiology, Coronary atherosclerosis, Prospective cohort study, Artery, Endocrinology
- MeSH
- coronary vessels, humans, disease progression, resorcinols, diet, diet surveys, feeding behavior, postmenopause, aged, middle aged, female, atherosclerosis, coronary artery disease, biomarkers, secale, whole grains
5 authors
From US, SE
- Nicola Mary McKeown · correspondingTufts University; Jean Mayer Human Nutrition Research Center on Aging
- Adela HrubyMassachusetts Department of Public Health; Harvard University
- Rikard LandbergKarolinska Institutet; Swedish University of Agricultural Sciences
- David M. HerringtonAtrium Health Wake Forest Baptist
- Alice Hinda LichtensteinTufts University; Jean Mayer Human Nutrition Research Center on Aging
Abstract
Objective
The objective of the present study was to examine the relationship between plasma alkyresorcinol (AR) concentrations, which are biomarkers of whole-grain intake, and atherosclerotic progression over 3 years in postmenopausal women with coronary artery disease.
Design
Plasma AR concentrations were measured by a validated GC-MS method in fasting plasma samples. Atherosclerosis progression was assessed using change in mean minimal coronary artery diameter (MCAD) and percentage diameter stenosis (%ST), based on mean proximal vessel diameter across up to ten coronary segments. Dietary intake was estimated using a 126-item interviewer-administered FFQ.
Setting
A prospective study of postmenopausal women participating in the Estrogen Replacement and Atherosclerosis trial.
Subjects
For the analysis of plasma AR concentrations and atherosclerotic progression, plasma samples and follow-up data on angiography were available for 182 women.
Results
Mean whole-grain intake was 9·6 (se 0·6) servings per week. After multivariate adjustment, no significant associations were observed between plasma AR concentrations and change in mean MCAD or progression of %ST. Plasma AR concentrations were significantly correlated with dietary whole grains (r=0·35, P<0·001), cereal fibre (r=0·33, P<0·001), bran (r=0·15, P=0·05), total fibre (r=0·22, P=0·003) and legume fibre (r=0·15, P=0·04), but not refined grains, fruit fibre or vegetable fibre.
Conclusions
Plasma AR concentrations were not significantly associated with coronary artery progression over a 3-year period in postmenopausal women with coronary artery disease. A moderate association was observed between plasma AR concentrations and dietary whole grains and cereal fibre, suggesting it may be a useful biomarker in observational studies.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
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