Whole Grain Consumption and Breast Cancer: A Case-Control Study in Women
Mourouti N, Kontogianni MD, Papavagelis C, Psaltopoulou T, Kapetanstrataki MG, Plytzanopoulou P, Vassilakou T, Malamos N, Linos A, Panagiotakos DB
Journal of the American College of Nutrition · 23 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Case-control study (indexed by PubMed)
- Studied in
- People
- Main outcome
- Clinical events such as disease or death
- Intake measured by
- Food frequency questionnaire
Who paid for it
- Funding
- Funding not disclosed
Publication
- Published
- 2015-04-27 · J Am Coll Nutr · vol. 35 · issue 2 · pp. 143–149
- Publisher
- Taylor & Francis
- Cited
- 42 citations · more than 94% of similar papers · 4.3× the field average
- Impact
- Top 10% most cited in its field
- References
- 24 works
- Access
- Paywalled
- Research areas
- Nutritional Studies and Diet · Food composition and properties · Cancer Risks and Factors
- Keywords
- Breast cancer, Medicine, Whole grains, Confidence interval, Odds ratio, Case-control study, Cancer, Consumption (sociology), Mediterranean diet, Demography, Internal medicine, Gynecology, Environmental health, Food science, Biology
- MeSH
- humans, breast neoplasms, obesity, hormone replacement therapy, diet, risk factors, case-control studies, feeding behavior, smoking, menopause, adult, aged, middle aged, female, whole grains
10 authors
From GR, US
- Niki MouroutiHarokopio University of Athens
- Meropi D. KontogianniHarokopio University of Athens
- Christos PapavagelisHarokopio University of Athens
- Theodora PsaltopoulouAthens State University
- Melpo KapetanstratakiHarokopio University of Athens
- Petrini PlytzanopoulouNational School of Public Health
Abstract
Objective
Whole grain consumption has long been associated with human health. However, its relationship with breast cancer remains not well understood and appreciated. The aim of this work was to evaluate the association between whole grain consumption and breast cancer in women.
Methods
A case-control study was designed. Two hundred and fifty consecutive, newly diagnosed breast cancer female patients (56 ± 12 years) and 250 one-to-one age-matched controls were enrolled. A standardized, validated questionnaire assessing various sociodemographic, clinical, lifestyle, and dietary characteristics was applied through face-to-face interviews. Moreover, data on regular consumption of whole grains (i.e., never/rarely, 1-6 times/week, >7 times/week) were recorded. Overall dietary habits were assessed through the level of adherence to the Mediterranean diet using the MedDietScore (theoretical range 0-55).
Results
Whole grain consumption of more than 7 times/week was associated with a 0.49-fold (odds ratio = 0.49; 95% confidence interval, 0.29, 0.82) lower likelihood of having breast cancer, after adjustments were made.
Conclusions
This study suggested that whole grain consumption more than 7 times/week was consistently associated with reduced risk of breast cancer.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
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