Caffeine-induced increase in voluntary activation and strength of the quadriceps muscle during isometric, concentric and eccentric contractions
Behrens M, Mau-Moeller A, Weippert M, Fuhrmann J, Wegner K, Skripitz R, Bader R, Bruhn S
Scientific reports · 73 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Randomized controlled trial (classified by our AI screen)
- Studied in
- People
- Main outcome
- Health markers and function
Who paid for it
- Funding
- Funding not disclosed
Publication
- Published
- 2015-05-13 · Sci Rep · vol. 5 · issue 1 · p. 10209
- Publisher
- Nature Portfolio
- Cited
- 98 citations · more than 99% of similar papers · 20.5× the field average
- Impact
- Top 10% most cited in its field
- References
- 40 works
- Access
- Open access (journal) · CC-BY
- Research areas
- Cardiovascular and exercise physiology · Exercise and Physiological Responses · Sports Performance and Training
- Keywords
- Isometric exercise, Concentric, Eccentric, Caffeine, Muscle contraction, Turnover, Medicine, Internal medicine, Placebo, Reflex, Crossover study, Ingestion, Endocrinology, Anesthesia, Physical medicine and rehabilitation, Physical therapy, Mathematics, Physics
- MeSH
- humans, caffeine, electromyography, evoked potentials, muscle contraction, adult, female, male, quadriceps muscle, muscle strength, young adult
8 authors
From DE
- Martin BehrensUniversity of Rostock
- Anett Mau‐Moeller
- Matthias WeippertUniversity of Rostock
- Josefin FuhrmannUniversity of Rostock
- Katharina Wegner
- Ralf Skripitz
Abstract
This study investigated effects of caffeine ingestion (8 mg/kg) on maximum voluntary torque (MVT) and voluntary activation of the quadriceps during isometric, concentric and eccentric contractions. Fourteen subjects ingested caffeine and placebo in a randomized, controlled, counterbalanced, double-blind crossover design. Neuromuscular tests were performed before and 1 h after oral caffeine and placebo intake. MVTs were measured and the interpolated twitch technique was applied during isometric, concentric and eccentric contractions to assess voluntary activation. Furthermore, normalized root mean square of the EMG signal was calculated and evoked spinal reflex responses (H-reflex evoked at rest and during weak isometric voluntary contraction) as well as twitch torques were analyzed. Caffeine increased MVT by 26.4 N m (95%CI: 9.3-43.5 N m, P = 0.004), 22.5 N m (95%CI: 3.1-42.0 N m, P = 0.025) and 22.5 N m (95%CI: 2.2-42.7 N m, P = 0.032) for isometric, concentric and eccentric contractions. Strength enhancements were associated with increases in voluntary activation. Explosive voluntary strength and voluntary activation at the onset of contraction were significantly increased following caffeine ingestion. Changes in spinal reflex responses and at the muscle level were not observed. Data suggest that caffeine ingestion induced an acute increase in voluntary activation that was responsible for the increased strength regardless of the contraction mode.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
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