Funded in part by Egg Nutrition Center
One Egg per Day Improves Inflammation when Compared to an Oatmeal-Based Breakfast without Increasing Other Cardiometabolic Risk Factors in Diabetic Patients
Ballesteros MN, Valenzuela F, Robles AE, Artalejo E, Aguilar D, Andersen CJ, Valdez H, Fernandez ML
Nutrients · 52 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Randomized controlled trial (indexed by PubMed)
- Studied in
- People
- Main outcome
- Health markers and function
- Intake measured by
- Food diaries or recalls
Who paid for it
- Funding
- Industry funded
- Industry group
- Egg Nutrition Center
- Authors
- At least one author declares a financial tie to industry
Based on 1 listed funder(s) and full-text disclosure statement.
Publication
- Published
- 2015-05-11 · Nutrients · vol. 7 · issue 5 · pp. 3449–3463
- Publisher
- Multidisciplinary Digital Publishing Institute
- Cited
- 75 citations · more than 95% of similar papers · 4.6× the field average
- Impact
- Top 10% most cited in its field
- References
- 46 works
- Access
- Open access (journal) · CC-BY
- Research areas
- Dietary Effects on Health · Nutritional Studies and Diet · Diet and metabolism studies
- Keywords
- Medicine, Inflammation, Diabetes mellitus, Internal medicine, Food science, Endocrinology, Biology
- MeSH
- humans, seeds, cardiovascular diseases, diabetic angiopathies, diabetes mellitus, type 2, inflammation mediators, risk factors, cross-over studies, single-blind method, nutrition policy, eggs, adult, aged, middle aged, mexico, female, male, diabetic cardiomyopathies, breakfast, avena, diet, diabetic, glycated hemoglobin
8 authors
From MX, US
- Martha BallesterosCentro de Investigación en Alimentación y Desarrollo
- Fabrizio ValenzuelaCentro de Investigación en Alimentación y Desarrollo
- Alma RoblesCentro de Investigación en Alimentación y Desarrollo
- Elizabeth ArtalejoCentro de Investigación en Alimentación y Desarrollo
- David AguilarUniversity of Connecticut
- Catherine J. AndersenUniversity of Connecticut
Abstract
There is concern that egg intake may increase blood glucose in patients with type 2 diabetes mellitus (T2DM). However, we have previously shown that eggs reduce inflammation in patients at risk for T2DM, including obese subjects and those with metabolic syndrome. Thus, we hypothesized that egg intake would not alter plasma glucose in T2DM patients when compared to oatmeal intake. Our primary endpoints for this clinical intervention were plasma glucose and the inflammatory markers tumor necrosis factor (TNF)-α and interleukin 6 (IL-6). As secondary endpoints, we evaluated additional parameters of glucose metabolism, dyslipidemias, oxidative stress and inflammation. Twenty-nine subjects, 35-65 years with glycosylated hemoglobin (HbA1c) values <9% were recruited and randomly allocated to consume isocaloric breakfasts containing either one egg/day or 40 g of oatmeal with 472 mL of lactose-free milk/day for five weeks. Following a three-week washout period, subjects were assigned to the alternate breakfast. At the end of each period, we measured all primary and secondary endpoints. Subjects completed four-day dietary recalls and one exercise questionnaire for each breakfast period. There were no significant differences in plasma glucose, our primary endpoint, plasma lipids, lipoprotein size or subfraction concentrations, insulin, HbA1c, apolipoprotein B, oxidized LDL or C-reactive protein. However, after adjusting for gender, age and body mass index, aspartate amino-transferase (AST) (p < 0.05) and tumor necrosis factor (TNF)-α (p < 0.01), one of our primary endpoints were significantly reduced during the egg period. These results suggest that compared to an oatmeal-based breakfast, eggs do not have any detrimental effects on lipoprotein or glucose metabolism in T2DM. In contrast, eggs reduce AST and TNF-α in this population characterized by chronic low-grade inflammation.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
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