Association between Dietary Magnesium Intake and Radiographic Knee Osteoarthritis
Zeng C, Li H, Wei J, Yang T, Deng ZH, Yang Y, Zhang Y, Yang TB, Lei GH
PloS one · 45 citations
How it was studied
- Design
- Cross-sectional study (indexed by PubMed)
- Studied in
- People
- Main outcome
- Clinical events such as disease or death
Who paid for it
- Funding
- Independent funding
- Government
- Development and Reform Commission of Hunan Province
- Government
- National Natural Science Foundation of China
- Government
- Ministry of Education of the People's Republic of China
- University or hospital
- Central South University
- Government
- Hunan Provincial Innovation Foundation for Postgraduate
- Government
- Fundamental Research Funds for the Central Universities
- Grants
- National Natural Science Foundation of China (No. 81201420, 81272034); National Natural Science Foundation of China (No. 81201420); Hunan Provincial Innovation Foundation for Postgraduate (81472130); Development and Reform Commission of Hunan Province (81472130); Development and Reform Commission of Hunan Province (81272034); National Natural Science Foundation of China (81201420); Central South University (81472130); National Natural Science Foundation of China (81272034); Central South University (81272034); National Natural Science Foundation of China (NO. 81201420, 81272034, 81472130); National Natural Science Foundation of China (14JJ3032); Central South University (14JJ3032); Development and Reform Commission of Hunan Province (14JJ3032); Hunan Provincial Innovation Foundation for Postgraduate (CX2014A005); Hunan Provincial Innovation Foundation for Postgraduate (14JJ3032); Hunan Provincial Innovation Foundation for Postgraduate (81272034); National Natural Science Foundation of China (2013SK2018); National Natural Science Foundation of China (81201420, 81272034, 81472130); National Natural Science Foundation of China (81472130)
Based on 6 listed funder(s) and full-text disclosure statement.
Publication
- Published
- 2015-05-26 · PLoS One · vol. 10 · issue 5 · p. e0127666
- Publisher
- Public Library of Science
- Cited
- 71 citations · more than 94% of similar papers · 4.4× the field average
- Impact
- Top 10% most cited in its field
- References
- 47 works
- Access
- Open access (journal) · CC-BY
- Research areas
- Magnesium in Health and Disease · Osteoarthritis Treatment and Mechanisms · Parathyroid Disorders and Treatments
- Keywords
- Medicine, Osteoarthritis, Odds ratio, Confounding, Confidence interval, Internal medicine, Cross-sectional study, Logistic regression, Pathology
- MeSH
- knee joint, humans, osteoarthritis, knee, disease progression, magnesium, radiography, diet, cross-sectional studies, adult, middle aged, female, male, osteophyte
9 authors
From CN
- Chao ZengCentral South University; Xiangya Hospital Central South University
- Hui LiCentral South University; Xiangya Hospital Central South University
- Jie WeiCentral South University
- Tuo YangCentral South University; Xiangya Hospital Central South University
- Zhenhan DengCentral South University; Xiangya Hospital Central South University
- Ye Seul YangCentral South University; Xiangya Hospital Central South University
Abstract
Objective
To examine the cross-sectional associations between dietary magnesium (Mg) intake and radiographic knee osteoarthritis (OA), joint space narrowing (JSN), and osteophytes (OST) respectively.
Methods
A total of 1626 subjects were included in the study. Dietary intake was assessed using a validated semi-quantitative food frequency questionnaire. Radiographic knee OA was defined as Kellgren-Lawrence (K-L) Grade 2 in at least one leg. JSN and OST were assessed individually according to the Osteoarthritis Research Society International (OARSI) atlas. A multivariable logistic analysis model was applied to test the various associations after adjusting for potentially confounding factors.
Results
The relative odds of radiographic knee OA were decreased by 0.53 times in the third quintile of Mg intake [odds ratio (OR) 0.53, 95% confidence interval (CI) 0.28-1.01], 0.40 times in the fourth quintile (OR 0.40, 95% CI 0.17-0.94) and 0.34 times in the fifth quintile (OR 0.34, 95% CI 0.11-1.00) compared with those in the lowest quintile, while P for trend was 0.111. The relative odds of JSN were decreased by 0.49 times in the third quintile of Mg intake (OR 0.49, 95% CI 0.28-0.88) and 0.37 times in the fifth quintile (OR 0.37, 95% CI 0.14-0.98) compared with those in the lowest quintile, while P for trend was 0.088. There was no significant relationship between dietary Mg intake and the presence of OST.
Conclusions
The findings of this cross-sectional study indicate that Mg intake is inversely associated with radiographic knee OA and JSN. It supports potential role of Mg in the prevention of knee OA.
Level of evidence
LevelIII, cross-sectional study.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
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