Funded in part by U.S. Highbush Blueberry Council
Blueberries improve endothelial function, but not blood pressure, in adults with metabolic syndrome: a randomized, double-blind, placebo-controlled clinical trial
Stull AJ, Cash KC, Champagne CM, Gupta AK, Boston R, Beyl RA, Johnson WD, Cefalu WT
Nutrients · 108 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Randomized controlled trial (indexed by PubMed)
- Studied in
- People
- Main outcome
- Health markers and function
- Intake measured by
- Food provided by researchers
Who paid for it
- Funding
- Industry funded
- Government
- Office of Dietary Supplements
- Industry group
- U.S. Highbush Blueberry Council
- University or hospital
- Louisiana Clinical and Translational Science Center
- Government
- National Institutes of Health
- Government
- National Institute of General Medical Sciences
- Government
- National Institute of Diabetes and Digestive and Kidney Diseases
- Government
- National Center for Research Resources
- Government
- National Center for Complementary and Integrative Health
- Government
- NCRR NIH HHS
- Government
- NIDDK NIH HHS
- Government
- NCCIH NIH HHS
- Government
- NIGMS NIH HHS
- Grants
- National Center for Complementary and Integrative Health (P50AT002776-01); National Institute of Diabetes and Digestive and Kidney Diseases (1P30DK072476); National Institute of General Medical Sciences (U54‐ GM104940); National Center for Complementary and Integrative Health (K01 AT006975); Office of Dietary Supplements (P50 AT002776); Louisiana Clinical and Translational Science Center (U54GM104940); National Institute of General Medical Sciences (GM104940); Louisiana Clinical and Translational Science Center (1 U54 GM104940); Louisiana Clinical and Translational Science Center (GM104940); Office of Dietary Supplements (1 U54 GM104940); National Center for Research Resources (P20 RR0-21945); National Institute of Diabetes and Digestive and Kidney Diseases (P30 DK-072476); National Center for Complementary and Integrative Health (P50 AT002776); National Center for Complementary and Integrative Health (U54 GM104940); National Institutes of Health (K01AT006975); National Institutes of Health (U54‐GM104940); National Institutes of Health (P50AT002776); National Institutes of Health (P20RR021945); National Institutes of Health (1U54‐GM‐104940); National Institutes of Health (DK072476); National Institutes of Health (1P30DK072476); National Institutes of Health (GM104940); National Institute of General Medical Sciences (1 U54 GM104940)
Based on 12 listed funder(s) and full-text disclosure statement.
Publication
- Published
- 2015-05-27 · Nutrients · vol. 7 · issue 6 · pp. 4107–4123
- Publisher
- Multidisciplinary Digital Publishing Institute
- Cited
- 167 citations · more than 98% of similar papers · 5.7× the field average
- Impact
- Top 10% most cited in its field
- References
- 56 works
- Access
- Open access (journal) · CC-BY
- Research areas
- Phytochemicals and Antioxidant Activities · Antioxidant Activity and Oxidative Stress · Pharmacology and Obesity Treatment
- Keywords
- Placebo, Blood pressure, Medicine, Ambulatory blood pressure, Metabolic syndrome, Randomized controlled trial, Ambulatory, Internal medicine, Reactive hyperemia, Insulin, Diabetes mellitus, Endocrinology, Blood flow, Pathology
- MeSH
- endothelium, vascular, humans, fruit, insulin resistance, body weight, cholesterol, insulin, blood glucose, triglycerides, blood pressure monitoring, ambulatory, body mass index, treatment outcome, double-blind method, body composition, blood pressure, middle aged, female, male, adiposity, blueberry plants, metabolic syndrome
8 authors
From US
- April J. Stull · correspondingPennington Biomedical Research Center; Louisiana State University System
- Katherine C. CashPennington Biomedical Research Center; Louisiana State University System
- Catherine M. ChampagnePennington Biomedical Research Center; Louisiana State University System
- ALOK KUMAR GUPTASoutheast Louisiana Veterans Health Care System
- Raymond C. BostonUniversity of Pennsylvania
- Robbie A. BeylPennington Biomedical Research Center; Louisiana State University System
Abstract
Blueberry consumption has been shown to have various health benefits in humans. However, little is known about the effect of blueberry consumption on blood pressure, endothelial function and insulin sensitivity in humans. The present study investigated the role of blueberry consumption on modifying blood pressure in subjects with metabolic syndrome. In addition, endothelial function and insulin sensitivity (secondary measurements) were also assessed. A double-blind and placebo-controlled study was conducted in 44 adults (blueberry, n = 23; and placebo, n = 21). They were randomized to receive a blueberry or placebo smoothie twice daily for six weeks. Twenty-four-hour ambulatory blood pressure, endothelial function and insulin sensitivity were assessed pre- and post-intervention. The blood pressure and insulin sensitivity did not differ between the blueberry and placebo groups. However, the mean change in resting endothelial function, expressed as reactive hyperemia index (RHI), was improved significantly more in the group consuming the blueberries versus the placebo group (p = 0.024). Even after adjusting for confounding factors, i.e., the percent body fat and gender, the blueberry group still had a greater improvement in endothelial function when compared to their counterpart (RHI; 0.32 ± 0.13 versus -0.33 ± 0.14; p = 0.0023). In conclusion, daily dietary consumption of blueberries did not improve blood pressure, but improved (i.e., increased) endothelial function over six weeks in subjects with metabolic syndrome.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
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