A meta-analysis of risk of pregnancy loss and caffeine and coffee consumption during pregnancy
Li J, Zhao H, Song JM, Zhang J, Tang YL, Xin CM
International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics · 58 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Meta-analysis (indexed by PubMed)
- Studied in
- People
- Main outcome
- Clinical events such as disease or death
Who paid for it
- Funding
- Funding not disclosed
Publication
- Published
- 2015-05-14 · Int J Gynaecol Obstet · vol. 130 · issue 2 · pp. 116–122
- Publisher
- Elsevier BV
- Cited
- 110 citations · more than 97% of similar papers · 6.9× the field average
- Impact
- Top 10% most cited in its field
- References
- 42 works
- Access
- Paywalled
- Research areas
- Coffee research and impacts · Gestational Diabetes Research and Management · Cancer Risks and Factors
- Keywords
- Medicine, Pregnancy, Caffeine, Obstetrics, Gynecology, Endocrinology
- MeSH
- humans, abortion, spontaneous, caffeine, risk, pregnancy, dose-response relationship, drug, coffee, female
6 authors
From CN
- Ji LiAnhui Medical University
- Hong Zhao
- Ju‐Min SongKunming Medical University
- Jing ZhangAnhui Medical University; Second Affiliated Hospital of Anhui Medical University
- Y. P. TangAnhui Medical University
- Chang‐Mao Xin · correspondingAnhui Medical University
Abstract
Background
Previous reports of the relationship between pregnancy loss and caffeine/coffee consumption have been inconsistent.
Objectives
To evaluate the association between pregnancy loss and caffeine and coffee consumption.
Search strategy
PubMed was searched for reports published before September 2014, with the keywords "caffeine," "coffee," "beverage," "miscarriage," "spontaneous abortion," and "fetal loss."
Selection criteria
Case-control and cohort studies were included when they had been reported in English, the exposure of interest was caffeine/coffee consumption during pregnancy, the outcome of interest was spontaneous abortion or fetal death, and multivariate-adjusted odds ratios (ORs) or risk ratios were provided or could be calculated.
Data collection and analysis
Data were extracted and combined ORs calculated.
Main results
Overall, 26 studies were included (20 of caffeine and eight of coffee). After adjustment for heterogeneity, caffeine consumption was associated with an increased risk of pregnancy loss (OR 1.32, 95% confidence interval [CI] 1.24-1.40), as was coffee consumption (OR 1.11, 95% CI 1.02-1.21). A dose-response analysis suggested that risk of pregnancy loss rose by 19% for every increase in caffeine intake of 150 mg/day and by 8% for every increase in coffee intake of two cups per day.
Conclusions
Consumption of caffeine and coffee during pregnancy seems to increase the risk of pregnancy loss.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
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