Caffeine and 3-km cycling performance: Effects of mouth rinsing, genotype, and time of day
Pataky MW, Womack CJ, Saunders MJ, Goffe JL, D'Lugos AC, El-Sohemy A, Luden ND
Scandinavian journal of medicine & science in sports · 69 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Randomized controlled trial (indexed by PubMed)
- Studied in
- People
- Main outcome
- Health markers and function
Who paid for it
- Funding
- Funding not disclosed
Publication
- Published
- 2015-06-09 · Scand J Med Sci Sports · vol. 26 · issue 6 · pp. 613–619
- Publisher
- Wiley
- Cited
- 107 citations · more than 96% of similar papers · 5.8× the field average
- Impact
- Top 10% most cited in its field
- References
- 37 works
- Access
- Paywalled
- Research areas
- Coffee research and impacts · Muscle metabolism and nutrition · Behavioral Health and Interventions
- Keywords
- Caffeine, Ingestion, Placebo, CYP1A2, Medicine, Cycling, Internal medicine, Oral administration, Genotype, Crossover study, Physiology, Animal science, Chemistry, Biology, Metabolism, Biochemistry
- MeSH
- mouth mucosa, humans, caffeine, cytochrome p-450 cyp1a2, mouthwashes, exercise test, administration, oral, double-blind method, circadian rhythm, heterozygote, homozygote, polymorphism, single nucleotide, time factors, female, male, athletic performance, young adult, performance-enhancing substances, administration, mucosal
7 authors
From US
- Mark William PatakyJames Madison University
- Christopher J. WomackJames Madison University
- M SaundersJames Madison University
- Jenna Louise GoffeJames Madison University
- Andrew C. D’LugosJames Madison University
- Ahmed El‐SohemyJames Madison University
Abstract
We assessed the efficacy of caffeine mouth rinsing on 3-km cycling performance and determined whether caffeine mouth rinsing affects performance gains influenced by the CYP1A2 polymorphism. Thirty-eight recreational cyclists completed four simulated 3-km time trials (TT). Subjects ingested either 6 mg/kg BW of caffeine or placebo 1 h prior to each TT. Additionally, 25 mL of 1.14% caffeine or placebo solution were mouth rinsed before each TT. The treatments were Placebo, caffeine Ingestion, caffeine Rinse and Ingestion+Rinse. Subjects were genotyped and classified as AA homozygotes or AC heterozygotes for the rs762551 polymorphism of the CYP1A2 gene involved in caffeine metabolism. Magnitude-based inferences were used to evaluate treatment differences in mean power output based on a predetermined meaningful treatment effect of 1.0%. AC heterozygotes (4.1%) and AA homozygotes (3.4%) benefited from Ingestion+Rinse, but only AC performed better with Ingestion (6.0%). Additionally, Rinse and Ingestion+Rinse elicited better performance relative to Placebo among subjects that performed prior to 10:00 h (Early) compared with after 10:00 h (Late). The present study provides additional evidence of genotype and time of day factors that affect the ergogenic value of caffeine intake that may allow for more personalized caffeine intake strategies to maximize performance.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
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