Effect of Low-Energy Diets Differing in Fiber, Red Meat, and Coffee Intake on Cardiac Autonomic Function in Obese Individuals With Type 2 Diabetes
Ziegler D, Strom A, Nowotny B, Zahiragic L, Nowotny PJ, Carstensen-Kirberg M, Herder C, Roden M
Diabetes care · 34 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Randomized controlled trial (indexed by PubMed)
- Studied in
- People
- Main outcome
- Health markers and function
- Intake measured by
- Not stated
Who paid for it
- Funding
- Funding not disclosed
Publication
- Published
- 2015-06-12 · Diabetes Care · vol. 38 · issue 9 · pp. 1750–1757
- Publisher
- American Diabetes Association
- Cited
- 39 citations · more than 89% of similar papers · 2.4× the field average
- References
- 42 works
- Access
- Paywalled
- Research areas
- Heart Rate Variability and Autonomic Control · Cardiovascular Syncope and Autonomic Disorders · Vagus Nerve Stimulation Research
- Keywords
- Medicine, Internal medicine, Heart rate variability, Diabetes mellitus, Type 2 diabetes, Endocrinology, Cardiac function curve, Insulin resistance, Heart rate, Cardiology, Heart failure, Blood pressure
- MeSH
- autonomic nervous system, humans, diabetes mellitus, type 2, obesity, caloric restriction, energy metabolism, coffee, dietary fiber, adult, middle aged, female, male, red meat
8 authors
From DE
- Dan Ziegler · correspondingDeutsches Diabetes-Zentrum e.V.; German Center for Diabetes Research; Heinrich Heine University Düsseldorf
- Alexander StromDeutsches Diabetes-Zentrum e.V.; German Center for Diabetes Research; Heinrich Heine University Düsseldorf
- Bettina NowotnyDeutsches Diabetes-Zentrum e.V.; Heinrich Heine University Düsseldorf
- Lejla ZahiragicDeutsches Diabetes-Zentrum e.V.; Heinrich Heine University Düsseldorf
- P. NowotnyDeutsches Diabetes-Zentrum e.V.; Heinrich Heine University Düsseldorf
- Maren Carstensen‐KirbergDeutsches Diabetes-Zentrum e.V.; German Center for Diabetes Research; Heinrich Heine University Düsseldorf
Abstract
Objective
The autonomic nervous system (ANS) regulates both the cardiovascular system and energy balance and is disturbed in diabetes and obesity. The effect of different approaches of caloric restriction on ANS function has not been assessed in individuals with diabetes. Thus, we sought to determine whether low-energy diets differing in fiber, red meat, and coffee intake exert differential effects on cardiac autonomic function.
Research design and methods
In this randomized parallel-group pilot trial, obese patients with type 2 diabetes were randomly allocated to consume either a diet high in cereal fiber, free of red meat, and high in coffee (n = 13) or a diet low in fiber, high in red meat, and coffee free (n = 15) over 8 weeks. Eight measures of heart rate variability (HRV) indicating vagal and/or sympathetic modulation over 3 h and inflammatory markers were determined during a hyperinsulinemic-euglycemic clamp.
Results
After 8 weeks, both dietary interventions resulted in a mean weight loss of 5-6 kg, a mean decline in heart rate of 4-6 bpm, and improvement in vagally mediated HRV. However, the changes in HRV parameters from baseline to 8 weeks did not differ between the groups. In the entire study cohort, incremental HRV from baseline to 8 weeks was associated with enhanced oxidative glucose utilization (P < 0.05), but not with insulin sensitivity and inflammatory markers.
Conclusions
In obese patients with type 2 diabetes, energy restriction per se over 8 weeks contributed to improved cardiac vagal function in relation to improved oxidative glucose utilization. This preliminary finding should be verified in a confirmatory trial.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
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