Dietary Intake of Sulforaphane-Rich Broccoli Sprout Extracts during Juvenile and Adolescence Can Prevent Phencyclidine-Induced Cognitive Deficits at Adulthood
Shirai Y, Fujita Y, Hashimoto R, Ohi K, Yamamori H, Yasuda Y, Ishima T, Suganuma H, Ushida Y, Takeda M, Hashimoto K
PloS one · 69 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Animal study (classified by our AI screen)
- Studied in
- People, plus animal or lab work
- Main outcome
- Health markers and function
Who paid for it
- Funding
- Possibly industry funded
- Government
- Ministry of Education, Culture, Sports, Science and Technology
- University or hospital
- Chiba University
- Government
- Japan Society for the Promotion of Science
- Authors
- At least one author declares a financial tie to industry
- Grants
- Ministry of Education, Culture, Sports, Science and Technology (24116006); Japan Society for the Promotion of Science (221S0003); Japan Society for the Promotion of Science (25293250); Japan Society for the Promotion of Science (15K09865)
Based on 3 listed funder(s) and full-text disclosure statement.
Publication
- Published
- 2015-06-24 · PLoS One · vol. 10 · issue 6 · p. e0127244
- Publisher
- Public Library of Science
- Cited
- 90 citations · more than 93% of similar papers · 3.3× the field average
- Impact
- Top 10% most cited in its field
- References
- 68 works
- Access
- Open access (journal) · CC-BY
- Research areas
- Genomics, phytochemicals, and oxidative stress · Tryptophan and brain disorders · Adenosine and Purinergic Signaling
- Keywords
- Sulforaphane, Phencyclidine, Oxidative stress, Cognitive deficit, Prepulse inhibition, Internal medicine, Medicine, Endocrinology, Schizophrenia (object-oriented programming), Pharmacology, Psychiatry, Disease, NMDA receptor, Cognitive impairment, Cancer research
- MeSH
- hippocampus, prefrontal cortex, animals, humans, mice, brassica, disease models, animal, isothiocyanates, sulfoxides, phencyclidine, intracellular signaling peptides and proteins, plant extracts, cognition disorders, schizophrenia, oxidative stress, adolescent, adult, middle aged, child, nf-e2-related factor 2, seedlings, kelch-like ech-associated protein 1
11 authors
From JP
- Yumi ShiraiCenter for Forensic Mental Health, Chiba University
- Yūkō FujitaCenter for Forensic Mental Health, Chiba University
- Ryota HashimotoThe University of Osaka
- Kazutaka OhiThe University of Osaka
- Hidenaga YamamoriThe University of Osaka
- Yuka YasudaThe University of Osaka
Abstract
Oxidative stress and inflammation play a role in cognitive impairment, which is a core symptom of schizophrenia. Furthermore, a hallmark of the pathophysiology of this disease is the dysfunction of cortical inhibitory γ-aminobutyric acid (GABA) neurons expressing parvalbumin (PV), which is also involved in cognitive impairment. Sulforaphane (SFN), an isothiocyanate derived from broccoli, is a potent activator of the transcription factor Nrf2, which plays a central role in the inducible expressions of many cytoprotective genes in response to oxidative stress. Keap1 is a cytoplasmic protein that is essential for the regulation of Nrf2 activity. Here, we found that pretreatment with SFN attenuated cognitive deficits, the increase in 8-oxo-dG-positive cells, and the decrease in PV-positive cells in the medial prefrontal cortex and hippocampus after repeated administration of phencyclidine (PCP). Furthermore, PCP-induced cognitive deficits were improved by the subsequent subchronic administration of SFN. Interestingly, the dietary intake of glucoraphanin (a glucosinolate precursor of SFN) during the juvenile and adolescence prevented the onset of PCP-induced cognitive deficits as well as the increase in 8-oxo-dG-positive cells and the decrease in PV-positive cells in the brain at adulthood. Moreover, the NRF2 gene and the KEAP1 gene had an epistatic effect on cognitive impairment (e.g., working memory and processing speed) in patients with schizophrenia. These findings suggest that SFN may have prophylactic and therapeutic effects on cognitive impairment in schizophrenia. Therefore, the dietary intake of SFN-rich broccoli sprouts during the juvenile and adolescence may prevent the onset of psychosis at adulthood.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
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