Caffeine Intake, Coffee Consumption, and Risk of Cutaneous Malignant Melanoma
Wu S, Han J, Song F, Cho E, Gao X, Hunter DJ, Qureshi AA
Epidemiology (Cambridge, Mass.) · 35 citations
How it was studied
- Design
- Cohort study (indexed by PubMed)
- Studied in
- People
- Main outcome
- Clinical events such as disease or death
Who paid for it
- Funding
- Independent funding
- Government
- National Cancer Institute
- Government
- National Center for Advancing Translational Sciences
- Government
- NCATS NIH HHS
- Government
- NCI NIH HHS
- Grants
- National Cancer Institute (P01 CA087969); National Cancer Institute (UM1 CA186107); National Cancer Institute (UM1-CA-167552); National Cancer Institute (UM1 CA176726); National Cancer Institute (R01CA137365); National Center for Advancing Translational Sciences (UL1TR-001108); National Cancer Institute ([P01 CA87969)
Based on 4 listed funder(s).
Publication
- Published
- 2015-07-14 · Epidemiology · vol. 26 · issue 6 · pp. 898–908
- Publisher
- Lippincott Williams & Wilkins
- Cited
- 45 citations · more than 96% of similar papers · 5.6× the field average
- Impact
- Top 10% most cited in its field
- References
- 43 works
- Access
- Open access (repository copy)
- Research areas
- Coffee research and impacts · Skin Protection and Aging · Tea Polyphenols and Effects
- Keywords
- Medicine, Caffeine, Melanoma, Hazard ratio, Confidence interval, Proportional hazards model, Lower risk, Cohort study, Cohort, Body mass index, Internal medicine
- MeSH
- humans, melanoma, skin neoplasms, caffeine, diet, proportional hazards models, cohort studies, follow-up studies, prospective studies, coffee, adult, aged, middle aged, united states, female, male
7 authors
From US, CN
- Shaowei Wu · correspondingIndiana University Health; Brigham and Women's Hospital; Harvard University; Indiana University Hospital; Indiana University – Purdue University Indianapolis
- Jiali HanBrown University
- Fengju SongRichard M. Fairbanks Foundation; Indiana University – Purdue University Indianapolis
- Eunyoung ChoIndiana University Health; Indiana Cancer Consortium; Indiana University – Purdue University Indianapolis
- Xiang GaoIndiana University – Purdue University Indianapolis
- David John HunterBrigham and Women's Hospital
Abstract
Background
Caffeine has been shown to prevent ultraviolet radiation-induced carcinogenesis and to inhibit growth of melanoma cells in experimental studies. We evaluated the association among caffeine intake, coffee consumption, and melanoma risk among three large cohort studies.
Methods
The analysis used data from 89,220 women in the Nurses' Health Study II (1991-2009), 74,666 women in the Nurses' Health Study (1980-2008), and 39,424 men in the Health Professionals Follow-up Study (1986-2008). We used Cox proportional hazards models to estimate the hazard ratios (HR) with 95% confidence intervals (CIs) of melanoma associated with dietary intakes.
Results
We documented 2,254 melanoma cases over 4 million person-years of follow-up. After adjustment for other risk factors, higher total caffeine intake was associated with a lower risk of melanoma (≥393 mg/day vs. <60 mg/day: HR = 0.78, 95% CI = 0.64, 0.96; Ptrend = 0.048). The association was more apparent in women (≥393 mg/day vs. <60 mg/day: HR = 0.70, 95% CI = 0.58, 0.85; Ptrend = 0.001) than in men (HR = 0.94, 95% CI = 0.75, 1.2; Ptrend = 0.81), and more apparent for melanomas occurring on body sites with higher continuous sun exposure (head, neck, and extremities; ≥393 mg/day vs. <60 mg/day: HR = 0.71, 95% CI = 0.59, 0.86; Ptrend = 0.001) than for melanomas occurring on body sites with lower continuous sun exposure (trunk including shoulder, back, hip, abdomen, and chest; HR = 0.90, 95% CI = 0.70, 1.2; Ptrend = 0.60). This pattern of association was similar to that for caffeinated coffee consumption, whereas no association was found for decaffeinated coffee consumption and melanoma risk.
Conclusions
Increasing caffeine intake and caffeinated coffee consumption is associated with decreased risk of cutaneous malignant melanomas.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
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