Acute Dietary Nitrate Intake Improves Muscle Contractile Function in Patients With Heart Failure: A Double-Blind, Placebo-Controlled, Randomized Trial
Coggan AR, Leibowitz JL, Spearie CA, Kadkhodayan A, Thomas DP, Ramamurthy S, Mahmood K, Park S, Waller S, Farmer M, Peterson LR
Circulation. Heart failure · 107 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Randomized controlled trial (indexed by PubMed)
- Studied in
- People
- Main outcome
- Health markers and function
- Intake measured by
- Food provided by researchers
Who paid for it
- Funding
- Independent funding
- Government
- National Center for Advancing Translational Sciences
- Government
- NCATS NIH HHS
- Grants
- National Center for Advancing Translational Sciences (UL1-TR-000448)
Based on 2 listed funder(s).
Publication
- Published
- 2015-07-16 · Circ Heart Fail · vol. 8 · issue 5 · pp. 914–920
- Publisher
- Lippincott Williams & Wilkins
- Cited
- 138 citations · more than 100% of similar papers · 37.7× the field average
- Impact
- Top 10% most cited in its field
- References
- 43 works
- Access
- Free to read
- Research areas
- Cardiovascular and exercise physiology · Exercise and Physiological Responses · Nitric Oxide and Endothelin Effects
- Keywords
- Medicine, Heart failure, Crossover study, Ingestion, Internal medicine, Placebo, Cardiology, Dietary Nitrate, Nitric oxide, Blood pressure, Bioavailability, Endocrinology, Nitrate, Nitrite, Pharmacology
- MeSH
- muscle, skeletal, humans, nitrates, exercise, pilot projects, cross-over studies, double-blind method, oxygen consumption, muscle contraction, dose-response relationship, drug, quality of life, dietary supplements, middle aged, female, male, heart failure
11 authors
- Andrew R. Coggan
- Joshua L. Leibowitz
- Catherine Anderson Spearie
- Ana Kadkhodayan
- Deepak P. Thomas
- Sujata Ramamurthy
Abstract
Background
Skeletal muscle strength, velocity, and power are markedly reduced in patients with heart failure, which contributes to their impaired exercise capacity and lower quality of life. This muscle dysfunction may be partially because of decreased nitric oxide (NO) bioavailability. We therefore sought to determine whether ingestion of inorganic nitrate (NO3 (-)) would increase NO production and improve muscle function in patients with heart failure because of systolic dysfunction.
Methods and results
Using a double-blind, placebo-controlled, randomized crossover design, we determined the effects of dietary NO3 (-) in 9 patients with heart failure. After fasting overnight, subjects drank beetroot juice containing or devoid of 11.2 mmol of NO3 (-). Two hours later, muscle function was assessed using isokinetic dynamometry. Dietary NO3 (-) increased (P<0.05-0.001) breath NO by 35% to 50%. This was accompanied by 9% (P=0.07) and 11% (P<0.05) increases in peak knee extensor power at the 2 highest movement velocities tested (ie, 4.71 and 6.28 rad/s). Maximal power (calculated by fitting peak power data with a parabola) was therefore greater (ie, 4.74±0.41 versus 4.20±0.33 W/kg; P<0.05) after dietary NO3 (-) intake. Calculated maximal velocity of knee extension was also higher after NO3 (-) ingestion (ie, 12.48±0.95 versus 11.11±0.53 rad/s; P<0.05). Blood pressure was unchanged, and no adverse clinical events occurred.
Conclusions
In this pilot study, acute dietary NO3 (-) intake was well tolerated and enhanced NO bioavailability and muscle power in patients with systolic heart failure. Larger-scale studies should be conducted to determine whether the latter translates into an improved quality of life in this population.
Clinical trial registration
URL: http://www.clinicaltrials.gov. Unique identifier: NCT01682356.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
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