Red meat allergic patients have a selective IgE response to the α-Gal glycan
Apostolovic D, Tran TA, Sánchez-Vidaurre S, Cirkovic Velickovic T, Starkhammar M, Hamsten C, van Hage M
Allergy · 22 citations
Review labels
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How it was studied
- Design
- In vitro/mechanistic study (classified by our AI screen)
- Studied in
- People
- Main outcome
- Mechanisms only
- Intake measured by
- Not stated
Who paid for it
- Funding
- Independent funding
- Nonprofit
- Hjärt-Lungfonden
- University or hospital
- Karolinska Institutet
- Government
- Stockholms Läns Landsting
- Government
- Vetenskapsrådet
- Government
- Ministarstvo Prosvete, Nauke i Tehnološkog Razvoja
- Nonprofit
- Magnus Bergvalls Stiftelse
- University or hospital
- Center for Inflammatory Diseases, Karolinska Institutet
- Nonprofit
- EAACI Fellowship Award 2013
- Nonprofit
- Swedish Cancer and Allergy Foundation
- Nonprofit
- Swedish Asthma and Allergy Association's Research Foundation
- Government
- FP7 RegPot project FCUB ERA
- Nonprofit
- King Gustaf V 80th Birthday Foundation
- Nonprofit
- Konsul Th C Berg Foundation
- Grants
- Ministarstvo Prosvete, Nauke i Tehnološkog Razvoja (172024)
Based on 13 listed funder(s).
Publication
- Published
- 2015-07-18 · Allergy · vol. 70 · issue 11 · pp. 1497–1500
- Publisher
- Wiley
- Cited
- 33 citations · more than 87% of similar papers · 2.3× the field average
- References
- 21 works
- Access
- Paywalled
- Research areas
- Food Allergy and Anaphylaxis Research · Allergic Rhinitis and Sensitization · Contact Dermatitis and Allergies
- Keywords
- Immunoglobulin E, Glycan, Red meat, Immunology, Allergy, Food allergy, Thyroglobulin, Anaphylaxis, Antibody, Chemistry, Medicine, Biochemistry, Food science, Glycoprotein
- MeSH
- humans, food hypersensitivity, polysaccharides, immunoglobulin e, cross reactions, adult, aged, middle aged, female, male, young adult, red meat
7 authors
From SE, RS
- Danijela ApostolovićKarolinska University Hospital; Karolinska Institutet; University of Belgrade
- Thi Anh Thu TranKarolinska University Hospital; Karolinska Institutet
- Sara Sánchez‐VidaurreKarolinska University Hospital; Karolinska Institutet
- Tanja Ćirković VeličkovićUniversity of Belgrade
- Maria StarkhammarStockholm South General Hospital
- Carl HamstenKarolinska University Hospital; Karolinska Institutet
Abstract
Galactose-α-1,3-galactose (α-Gal) is a mammalian carbohydrate with significance in a novel type of food allergy. Patients with IgE against α-Gal report severe allergic symptoms 3-6 h after consumption of red meat. We investigated whether IgE from red meat allergic patients recognizes other mammalian glycans than α-Gal or glycans from the plant kingdom and insects of importance in allergy. We found that none of the 24 red meat allergic patients investigated had an IgE antibody response against the other abundant mammalian glycan N-glycolylneuraminic acid or against cross-reactive carbohydrate determinants from plant or venom sources (nCup a 1, nArt v 1, and MUXF3). Deglycosylation of an α-Gal-containing protein, bovine thyroglobulin, significantly reduced the IgE response. In conclusion, we show that red meat allergic patients have a selective IgE response to the α-Gal glycan found in red meat. Other common glycans reactive in allergic disease are not targets of red meat allergic patients' IgE.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
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