Extra virgin olive oil use is associated with improved post-prandial blood glucose and LDL cholesterol in healthy subjects
Violi F, Loffredo L, Pignatelli P, Angelico F, Bartimoccia S, Nocella C, Cangemi R, Petruccioli A, Monticolo R, Pastori D, Carnevale R
Nutrition & diabetes · 77 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Randomized controlled trial (classified by our AI screen)
- Studied in
- People
- Main outcome
- Health markers and function
- Intake measured by
- Food provided by researchers
Who paid for it
- Funding
- Funding not disclosed
Publication
- Published
- 2015-07-20 · Nutr Diabetes · vol. 5 · issue 7 · p. e172
- Publisher
- Springer Nature
- Cited
- 112 citations · more than 94% of similar papers · 4.4× the field average
- Impact
- Top 10% most cited in its field
- References
- 19 works
- Access
- Open access (journal) · CC-BY
- Research areas
- Edible Oils Quality and Analysis · Nutritional Studies and Diet · Nuts composition and effects
- Keywords
- Medicine, Internal medicine, Meal, Glycemic, Mediterranean diet, Endocrinology, Cholesterol, Lipid profile, Olive oil, Type 2 diabetes, Glucagon-like peptide-1, Incretin, Insulin, Food science, Diabetes mellitus, Chemistry
11 authors
From IT
- Francesco Violi · correspondingSapienza University of Rome
- Lorenzo LoffredoSapienza University of Rome
- Pasquale PignatelliSapienza University of Rome
- Francesco AngelicoSapienza University of Rome
- Simona BartimocciaSapienza University of Rome
- Cristina NocellaSapienza University of Rome
Abstract
Objectives
Extra virgin olive oil (EVOO) is a key component of the Mediterranean diet and seems to account for the protective effect against cardiovascular disease. However, the underlying mechanism is still elusive.
Design
We tested the effect of EVOO, added to Mediterranean-type meal, on post-prandial glycemic and lipid profile.
Subjects
Post-prandial glycemic and lipid profile were investigated in 25 healthy subjects who were randomly allocated in a cross-over design to a Mediterranean-type meal added with or without 10 g EVOO (first study), or Mediterranean-type meal with EVOO (10 g) or corn oil (10 g; second study). Glycemic profile, which included glucose, insulin, dipeptidyl-peptidase-4 (DPP-4) protein and activity, glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP), and lipid profile, which included, low-density lipoprotein (LDL) cholesterol (LDL-C), oxidized LDL (ox-LDL), triglycerides and high-density lipoprotein (HDL) cholesterol (HDL-C), were analyzed before and 2 h after the meal.
Results
In the first study, 2 h after meal, subjects who assumed a meal with EVOO had significantly lower blood glucose (P<0.001), DPP-4 protein (P<0.001) and activity (P<0.001), LDL-C (P<0.001) and ox-LDL (P<0.001) and higher insulin (P<0.05), GLP-1 (P<0.001) and GIP (P<0.05) compared with those without EVOO. The second study showed that compared with corn oil, EVOO improved both glycemic and lipid profile. Thus, a significantly smaller increase of glucose (P<0.05), DPP4 protein (P<0.001) and activity (P<0.05) and higher increase of insulin (P<0.001) and GLP-1 (P<0.001) were observed. Furthermore, compared with corn oil, EVOO showed a significantly less increase of LDL-C (P<0.05) and ox-LDL (P<0.001).
Conclusions
We report for the first time that EVOO improves post-prandial glucose and LDL-C, an effect that may account for the antiatherosclerotic effect of the Mediterranean diet.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
Community trust
Loading…
How much do you trust this study's findings?
Comments
Sign in to rate, comment on or flag this study.Sign inSomething wrong here?
Flag this study if its information, labels or funding look wrong. An editor reviews every flag.
Sign in to rate, comment on or flag this study.Sign inEducational information about published research. Not medical advice, and not a recommendation to start or stop anything.