Funded in part by AlzChem AG (Germany)
Effects of long-term low-dose dietary creatine supplementation in older women
Lobo DM, Tritto AC, da Silva LR, de Oliveira PB, Benatti FB, Roschel H, Nieß B, Gualano B, Pereira RM
Experimental gerontology · 47 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Randomized controlled trial (indexed by PubMed)
- Studied in
- People
- Main outcome
- Health markers and function
Who paid for it
- Funding
- Industry funded
- Government
- Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
- Government
- Conselho Nacional de Desenvolvimento Científico e Tecnológico
- Government
- Conselho Nacional de Pesquisa e Desenvolvimento (CNPq)
- Government
- CAPES
- Company
- AlzChem AG (Germany)
Based on 5 listed funder(s).
Publication
- Published
- 2015-07-17 · Exp Gerontol · vol. 70 · pp. 97–104
- Publisher
- Elsevier BV
- Cited
- 66 citations · more than 81% of similar papers · 1.6× the field average
- References
- 45 works
- Access
- Open access (hybrid journal) · CC-BY-NC-ND
- Research areas
- Muscle metabolism and nutrition · Nutrition and Health in Aging · Cardiovascular and exercise physiology
- Keywords
- Creatine, Medicine, Lean body mass, Adverse effect, Placebo, Creatine Monohydrate, Bone mineral, Osteoporosis, Randomized controlled trial, Femoral neck, Internal medicine, Osteopenia, Bone density, Body mass index, Physical therapy, Physiology, Body weight
- MeSH
- muscle, skeletal, humans, bone diseases, metabolic, creatine, absorptiometry, photon, double-blind method, bone remodeling, body composition, bone density, dose-response relationship, drug, dietary supplements, aged, middle aged, female, biomarkers
9 authors
From BR, DE
- Daniel Medeiros LoboHospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo
- Aline C. TrittoUniversidade de São Paulo
- Luana Rodrigues da SilvaHospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo
- Paloma Borges de OliveiraHospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo
- Fabiana Braga BenattiHospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo
- Hamilton RoschelHospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo
Abstract
Objective
We aimed to investigate the effects of a one-year low-dose creatine supplementation trial on bone health, lean mass, and muscle function in older postmenopausal women.
Methods
A double-blind, randomized, parallel-group, placebo controlled trial was conducted between November 2011 and November 2013 in Sao Paulo, Brazil. Postmenopausal osteopenic women were randomly allocated (1:1) into creatine (n=56; 1g/d) or placebo group (n=53; dextrose at same dose). At baseline and after one year of intervention, we assessed parameters of bone health, body composition, and muscle function. Blood parameters were also assessed before and after the intervention and adverse events were recorded throughout the trial. Possible differences in dietary intake were assessed by three 24-h dietary recalls.
Results
Bone mineral density at lumbar spine, femoral neck, total femur, and whole body did not differ within- or between-groups. No significant changes in body weight, BMI, absolute and relative body fat, and body lean mass were observed. Muscle function, as assessed by timed-up-and-go and timed-stands tests, were not significantly changed within- or between-groups. Safety laboratory parameters remained unaltered.
Conclusion
A one-year low-dose creatine supplementation (1g/d) was free of adverse effects, but did not affect bone health parameters, lean mass, or muscle function in older women. Further studies with longer follow-up periods and higher doses of creatine supplementation are warranted. (Registered at clinicaltrials.gov as NCT01472393).
Abstract via Europe PMC. Copyright remains with the authors or publisher.
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