Maternal Caffeine Consumption during Pregnancy and Risk of Low Birth Weight: A Dose-Response Meta-Analysis of Observational Studies
Rhee J, Kim R, Kim Y, Tam M, Lai Y, Keum N, Oldenburg CE
PloS one · 64 citations
How it was studied
- Design
- Meta-analysis (indexed by PubMed)
- Studied in
- People
- Main outcome
- Clinical events such as disease or death
Who paid for it
- Funding
- Independent funding
- University or hospital
- Harvard T.H. Chan School of Public Health
- Government
- National Institute of Mental Health
- Government
- National Institute on Drug Abuse
- Government
- National Institute of Allergy and Infectious Diseases
- Government
- NIMH NIH HHS
- Government
- NIDA NIH HHS
- Government
- NIAID NIH HHS
- Grants
- National Institute on Drug Abuse (T32-DA013911); National Institute of Allergy and Infectious Diseases (T32-AI-007535); National Institute of Mental Health (R25 MH 083620)
Based on 7 listed funder(s) and full-text disclosure statement.
Publication
- Published
- 2015-07-20 · PLoS One · vol. 10 · issue 7 · p. e0132334
- Publisher
- Public Library of Science
- Cited
- 114 citations · more than 85% of similar papers · 1.8× the field average
- References
- 50 works
- Access
- Open access (journal) · CC-BY
- Research areas
- Gestational Diabetes Research and Management · Obesity, Physical Activity, Diet · Birth, Development, and Health
- Keywords
- Caffeine, Medicine, Pregnancy, Publication bias, Meta-analysis, Funnel plot, Odds ratio, Low birth weight, Cohort study, Obstetrics, Relative risk, Birth weight, Observational study, Confidence interval, Internal medicine, Biology
- MeSH
- humans, birth weight, caffeine, pregnancy, coffee, infant, newborn, infant, low birth weight, female
7 authors
From US
- Jongeun Rhee · correspondingHarvard University
- Rockli KimHarvard University
- Yongjoo KimHarvard University
- Melanie TamHarvard Global Health Institute
- Yizhen LaiHarvard University
- NaNa KeumHarvard University
Abstract
Epidemiologic studies have shown inconsistent conclusions about the effect of caffeine intake during pregnancy on the risk of low birth weight (LBW). We performed a meta-analysis and linear-dose response analysis examining the association between caffeine consumption during pregnancy and risk of LBW. PubMed and EMBASE were searched for relevant articles published up to March 2014. Eight cohort and four case-control studies met all inclusion criteria. Using a random-effects model of the twelve studies, the pooled odds ratio (OR) for the risk of LBW comparing the highest versus lowest level of caffeine intake during pregnancy was 1.38 (95% CI: 1.10, 1.73). Linear dose-response analysis showed that every additional 100 mg of caffeine intake (1 cup of coffee or 2 cups of tea) per day during pregnancy was associated with a 3.0% increase in OR for LBW. There was a moderate level of overall heterogeneity with an I-squared value of 55% (95% CI: 13, 76%), and no evidence of publication bias based on Egger's test (P = 0.20) and the funnel plot. Thus, high caffeine intake during pregnancy is associated with a significant increase in the risk of LBW, and this risk appears to increase linearly as caffeine intake increases.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
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