Nonlinear Reduction in Risk for Type 2 Diabetes by Magnesium Intake: An Updated Meta-Analysis of Prospective Cohort Studies
Xu T, Chen GC, Zhai L, Ke KF
Biomedical and environmental sciences : BES · 18 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Meta-analysis (indexed by PubMed)
- Studied in
- People
- Main outcome
- Clinical events such as disease or death
Who paid for it
- Funding
- Funding not disclosed
Publication
- Published
- 2015-07-01 · Biomed Environ Sci · vol. 28 · issue 7 · pp. 527–34
- Publisher
- National Institutes of Health
- Cited
- 22 citations · more than 59% of similar papers · 0.6× the field average
- References
- 35 works
- Access
- Paywalled
- Research areas
- Magnesium in Health and Disease · Therapeutic Uses of Natural Elements · Plant Micronutrient Interactions and Effects
- Keywords
- Medicine, Meta-analysis, Type 2 diabetes, Diabetes mellitus, Prospective cohort study, Cohort study, Internal medicine, Relative risk, Subgroup analysis, Magnesium, Endocrinology, Confidence interval, Chemistry
- MeSH
- humans, diabetes mellitus, type 2, magnesium, risk, least-squares analysis, prospective studies, dose-response relationship, drug, nonlinear dynamics
4 authors
From CN
- Xu TianNantong University; Affiliated Hospital of Nantong University
- Guo Chong ChenNantong University; Affiliated Hospital of Nantong University
- Lin ZhaiNantong University; Affiliated Hospital of Nantong University
- Kai Fu KeNantong University; Affiliated Hospital of Nantong University
Abstract
Observational studies between magnesium int- ake and risk of type 2 diabetes yielded inconsistent results. We conducted a system literature search of PubMed database through March 2015 for prospective cohort studies of magnesium intake and type 2 diabetes risk. Study-specific results were pooled in a random-effects model. Subgroup and sensitivity analysis were performed to assess the potential sources of heterogeneity and the robustness of the pooled estimation. Generalized least squares trend estimation was used to investigate the dose-response relationship. A total of 15 papers with 19 analyses were identified with 539,735 participants and 25,252 incident diabetes cases. Magnesium intake was associated with a significant lower risk of type 2 diabetes (RR: 0.77; 95% CI: 0.71-0.82) for the highest compared with lowest category. This association was not significantly modified by the pre-specified study characteristics. In the dose-response analysis, a magnesium intake increment of 100 mg/day was associated with a 16% reduction in type 2 diabetes risk (RR: 0.84; 95% CI: 0.80-0.88). A nonlinear relationship existed between magnesium intake and type 2 diabetes (P-nonlinearity=0.003). This meta-analysis further verified a protective effect of magnesium intake on type 2 diabetes in a nonlinear dose-response manner.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
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