Funded in part by Sanofi, Meat and Livestock Australia
The effects of a protein enriched diet with lean red meat combined with a multi-modal exercise program on muscle and cognitive health and function in older adults: study protocol for a randomised controlled trial
Daly RM, Gianoudis J, Prosser M, Kidgell D, Ellis KA, O'Connell S, Nowson CA
Trials · 36 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Randomized controlled trial (indexed by PubMed)
- Studied in
- People
- Main outcome
- Health markers and function
- Intake measured by
- Food provided by researchers
Who paid for it
- Funding
- Industry funded
- Company
- Sanofi
- Industry group
- Meat and Livestock Australia
Based on 2 listed funder(s) and full-text disclosure statement.
Publication
- Published
- 2015-08-07 · Trials · vol. 16 · issue 1 · p. 339
- Publisher
- Springer Science+Business Media
- Cited
- 50 citations · more than 88% of similar papers · 2.4× the field average
- References
- 82 works
- Access
- Open access (journal) · CC-BY
- Research areas
- Muscle metabolism and nutrition · Nutrition and Health in Aging · Nutritional Studies and Diet
- Keywords
- Medicine, Lean body mass, Red meat, Wasting, Cognition, Physical therapy, Cognitive decline, Gerontology, Dementia, Internal medicine, Body weight, Pathology
- MeSH
- muscle, skeletal, humans, dietary proteins, treatment outcome, clinical protocols, combined modality therapy, geriatric assessment, mental health, cognition, cognition disorders, age factors, aging, research design, time factors, quality of life, aged, victoria, female, male, muscle strength, resistance training, sarcopenia, biomarkers, surveys and questionnaires, red meat
7 authors
From AU
- Robin M. Daly · correspondingDeakin University
- Jenny GianoudisDeakin University
- Melissa ProsserDeakin University
- Dawson J. KidgellDeakin University; La Trobe University
- Kathryn A. EllisThe University of Melbourne
- Stella L. O’ConnellDeakin University
Abstract
Background
Age-related muscle wasting has been strongly implicated with falls and fractures in the elderly, but it has also been associated with cognitive decline and dementia. Progressive resistance training (PRT) and adequate dietary protein are recognised as important contributors to the maintenance of muscle health and function in older adults. However, both factors also have the potential to improve brain function and prevent cognitive decline via several pathways, including the regulation of various growth and neurotrophic factors [insulin-like growth factor-1 (IGF-1)]; brain-derived growth factor (BDNF)] and/or the modulation of systemic inflammation. The primary aim of this study is to investigate whether a modest increase in dietary protein achieved through the consumption of lean red meat three days per week, when combined with PRT, can enhance muscle mass, size and strength and cognitive function in community-dwelling older people.
Methods/design
The study design is a 48-week randomised controlled trial consisting of a 24-week intervention with a 24-week follow-up. Men and women (n=152) aged 65 years and over residing in the community will be randomly allocated to: 1) PRT and provided with 220 g (raw weight) of lean red meat to be cooked and divided into two 80 g servings on each of the three days that they complete their exercise session, or 2) control PRT in which participants will be provided with and advised to consume ≥1 serving (~1/2 cup) of rice and/or pasta or 1 medium potato on each of the three training days. The primary outcome measures will be muscle mass, size and strength and cognitive function. Secondary outcomes will include changes in: muscle function, neural health (corticospinal excitability and inhibition and voluntary activation), serum IGF-1 and BDNF, adipokines and inflammatory markers, fat mass and inter-/intra-muscular fat, blood pressure, lipids and health-related quality of life. All outcome measures will be assessed at baseline and 24 weeks, with the exception of cognitive function and the various neurobiological and inflammatory markers which will also be assessed at week 12.
Discussion
The findings from this study will provide important new information on whether a modest increase in dietary protein achieved through the ingestion of lean red meat can enhance the effects of PRT on muscle mass, size and strength as well as cognitive function in community-dwelling older adults. If successful, the findings will form the basis for more precise exercise and nutrition guidelines for the management and prevention of age-related changes in muscle and neural health and cognitive function in the elderly.
Trial registration
Australian New Zealand Clinical Trials Registry: ACTRN12613001153707 . Date registered 16(th) October, 2013.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
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