Coffee, tea, caffeine intake, and the risk of cancer in the PLCO cohort
Hashibe M, Galeone C, Buys SS, Gren L, Boffetta P, Zhang ZF, La Vecchia C
British journal of cancer · 91 citations
How it was studied
- Design
- Cohort study (indexed by PubMed)
- Studied in
- People
- Main outcome
- Clinical events such as disease or death
Who paid for it
- Funding
- Independent funding
- Government
- National Cancer Institute
- Government
- NCI NIH HHS
- Grants
- National Cancer Institute (T32 CA009142)
Based on 2 listed funder(s).
Publication
- Published
- 2015-08-20 · Br J Cancer · vol. 113 · issue 5 · pp. 809–816
- Publisher
- Springer Nature
- Cited
- 124 citations · more than 99% of similar papers · 11.7× the field average
- Impact
- Top 10% most cited in its field
- References
- 46 works
- Access
- Open access (hybrid journal) · CC-BY-NC-SA
- Research areas
- Coffee research and impacts · Tea Polyphenols and Effects · Cancer Risks and Factors
- Keywords
- Medicine, Caffeine, Cancer, Endometrial cancer, Internal medicine, Relative risk, Confidence interval, Ovarian cancer, Prostate cancer, Cohort, Cohort study, Oncology, Physiology, Gynecology
- MeSH
- humans, colorectal neoplasms, ovarian neoplasms, lung neoplasms, prostatic neoplasms, caffeine, risk factors, prospective studies, coffee, tea, aged, middle aged, female, male
7 authors
From US, IT
- Mia Hashibe · correspondingUniversity of Utah; Huntsman Cancer Institute
- Carlotta GaleoneUniversity of Milano-Bicocca
- Saundra S. BuysUniversity of Utah; Huntsman Cancer Institute
- Lisa H. GrenUniversity of Utah
- Paolo BoffettaTisch Hospital; Icahn School of Medicine at Mount Sinai
- Zuo‐Feng ZhangUniversity of California, Los Angeles; UCLA Health
Abstract
Background
The association between coffee intake, tea intake and cancer has been extensively studied, but associations are not established for many cancers. Previous studies are not consistent on whether caffeine may be the source of possible associations between coffee and cancer risk.
Methods
In the Prostate, Lung, Colorectal, and Ovarian cancer screening trial, of the 97,334 eligible individuals, 10,399 developed cancer. Cancers included were 145 head and neck, 99 oesophageal, 136 stomach, 1137 lung, 1703 breast, 257 endometrial, 162 ovarian, 3037 prostate, 318 kidney, 398 bladder, 103 gliomas, and 106 thyroid.
Results
Mean coffee intake was higher in lower education groups, among current smokers, among heavier and longer duration smokers, and among heavier alcohol drinkers. Coffee intake was not associated with the risk of all cancers combined (RR=1.00, 95% confidence interval (CI)=0.96-1.05), whereas tea drinking was associated with a decreased risk of cancer overall (RR=0.95, 95% CI=0.94-0.96 for 1+ cups per day vs <1 cup per day). For endometrial cancer, a decreased risk was observed for coffee intake (RR=0.69, 95% CI=0,52-0.91 for ⩾2 cups per day). Caffeine intake was not associated with cancer risk in a dose-response manner.
Conclusions
We observed a decreased risk of endometrial cancer for coffee intake, and a decreased risk of cancer overall with tea intake.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY-NC-SA).
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