Funded in part by Pfizer, Pfizer Foundation
Nut consumption is inversely associated with both cancer and total mortality in a Mediterranean population: prospective results from the Moli-sani study
Bonaccio M, Di Castelnuovo A, De Curtis A, Costanzo S, Bracone F, Persichillo M, Donati MB, de Gaetano G, Iacoviello L, Moli-sani Project investigators
The British journal of nutrition · 41 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Cohort study (indexed by PubMed)
- Studied in
- People
- Main outcome
- Clinical events such as disease or death
- Intake measured by
- Food frequency questionnaire
Who paid for it
- Funding
- Industry funded
- Company
- Pfizer
- Government
- Ministero dell’Istruzione, dell’Università e della Ricerca
- Nonprofit
- Fondazione Umberto Veronesi
- Government
- Regione Molise
- Company
- Pfizer Foundation
Based on 5 listed funder(s).
Publication
- Published
- 2015-08-27 · Br J Nutr · vol. 114 · issue 5 · pp. 804–811
- Publisher
- Cambridge University Press
- Cited
- 53 citations · more than 96% of similar papers · 5.6× the field average
- Impact
- Top 10% most cited in its field
- References
- 45 works
- Access
- Free to read
- Research areas
- Nuts composition and effects · Nutritional Studies and Diet · Nutrition, Health and Food Behavior
- Keywords
- Medicine, Hazard ratio, Nut, Prospective cohort study, Mediterranean diet, Proportional hazards model, Cancer, Confounding, Population, Internal medicine, Epidemiology, Demography, Confidence interval, Environmental health
- MeSH
- humans, nuts, neoplasms, cardiovascular diseases, inflammation, c-reactive protein, cause of death, proportional hazards models, risk factors, prospective studies, diet, mediterranean, adult, aged, middle aged, italy, female, male, biomarkers, surveys and questionnaires
9 authors
From IT
- Marialaura Bonaccio · correspondingIstituto Neurologico Mediterraneo; Fondazione Umberto Veronesi
- Augusto Filippo Di CastelnuovoIstituto Neurologico Mediterraneo
- Amalia De CurtisIstituto Neurologico Mediterraneo
- Simona CostanzoIstituto Neurologico Mediterraneo
- Francesca BraconeIstituto Neurologico Mediterraneo
- Mariarosaria PersichilloIstituto Neurologico Mediterraneo
Abstract
Nut intake has been associated with reduced inflammatory status and lower risk of CVD and mortality. The aim of this study was to examine the relationship between nut consumption and mortality and the role of inflammation. We conducted a population-based prospective investigation on 19 386 subjects enrolled in the Moli-sani study. Food intake was recorded by the Italian version of the European Project Investigation into Cancer and Nutrition FFQ. C-reactive protein, leucocyte and platelet counts and the neutrophil:lymphocyte ratio were used as biomarkers of low-grade inflammation. Hazard ratios (HR) were calculated using multivariable Cox proportional hazard models. During a median follow-up of 4·3 years, 334 all-cause deaths occurred. As compared with subjects who never ate nuts, rare intake (≤2 times/month) was inversely associated with mortality (multivariable HR=0·68; 95 % CI 0·54, 0·87). At intake ≥8 times/month, a greater protection was observed (HR=0·53; 0·32, 0·90). Nut intake (v. no intake) conveyed a higher protection to individuals poorly adhering to the Mediterranean diet (MD). A significant reduction in cancer deaths (HR=0·64; 95 % CI 0·44, 0·94) was also observed, whereas the impact on CVD deaths was limited to an inverse, but not significant, trend. Biomarkers of low-grade inflammation were reduced in nut consumers but did not account for the association with mortality. In conclusion, nut intake was associated with reduced cancer and total mortality. The protection was stronger in individuals with lower adherence to MD, whereas it was similar in high-risk groups (diabetics, obese, smokers or those with the metabolic syndrome), as compared with low-risk subjects. Inflammation did not explain the observed relationship.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
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