Associations between cruciferous vegetable intake and selected biomarkers among women scheduled for breast biopsies
Zhang Z, Atwell LL, Farris PE, Ho E, Shannon J
Public health nutrition · 31 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Randomized controlled trial (indexed by PubMed)
- Studied in
- People
- Main outcome
- Mechanisms only
- Intake measured by
- Food frequency questionnaire
Who paid for it
- Funding
- Independent funding
- Government
- National Cancer Institute
- Government
- National Institute of Environmental Health Sciences
- Government
- National Center for Advancing Translational Sciences
- Government
- NCATS NIH HHS
- Government
- NCI NIH HHS
- Government
- NIEHS NIH HHS
- Grants
- National Institute of Environmental Health Sciences (P30ES000210); National Center for Advancing Translational Sciences (UL1TR000128); National Cancer Institute (R21 CA132236-01A2); National Cancer Institute (P01 CA090890); National Cancer Institute (R21 CA132236)
Based on 6 listed funder(s).
Publication
- Published
- 2015-09-02 · Public Health Nutr · vol. 19 · issue 7 · pp. 1288–1295
- Publisher
- Cambridge University Press
- Cited
- 40 citations · more than 72% of similar papers · 0.8× the field average
- References
- 29 works
- Access
- Free to read
- Research areas
- Genomics, phytochemicals, and oxidative stress · Kruppel-like factors research · Glutathione Transferases and Polymorphisms
- Keywords
- Cruciferous vegetables, Medicine, Internal medicine, Biopsy, Oncology, Sulforaphane, Gynecology, Physiology, Breast cancer, Cancer, Cancer research
- MeSH
- humans, vegetables, carcinoma, intraductal, noninfiltrating, breast neoplasms, isothiocyanates, sulfoxides, creatinine, histone deacetylases, ki-67 antigen, biopsy, body mass index, diet, nutrition assessment, multivariate analysis, linear models, double-blind method, life style, cell proliferation, socioeconomic factors, adult, aged, middle aged, female, biomarkers
5 authors
From US
- Zhenzhen Zhang · correspondingOregon Health & Science University
- Lauren L. AtwellOregon State University
- Paige E. FarrisOregon Health & Science University
- Emily H. HoOregon State University
- Jackilen ShannonOregon Health & Science University
Abstract
Objective
To examine the relationship between dietary cruciferous vegetable intake and selected tumour biomarkers for histone acetylation (H3K9ac, H3K18ac, HDAC3 and HDAC6), proliferation (Ki-67) and cell-cycle regulation (p21) from breast tissue.
Design
The study used baseline data of women recruited to participate in a clinical trial of sulforaphane supplement. Dietary cruciferous vegetable intake was collected through a validated Arizona Cruciferous Vegetable Intake Questionnaire. Breast tissue was obtained from biopsy samples. Spearman correlations were calculated between intake of specific cruciferous vegetables and biomarkers. Tissue biomarkers were log2-transformed to obtain approximate normality. Linear regression analyses were conducted to examine associations between cruciferous vegetable intake and biomarkers adjusting for age and use of non-steroidal anti-inflammatory drugs. False discovery rate (FDR) was used to account for multiple comparisons.
Setting
Clinical trial baseline.
Subjects
Fifty-four women who had abnormal mammogram findings and were scheduled for breast biopsy.
Results
Mean intake of total cruciferous vegetables from all food sources was 81·7 (sd 57·3) g/d. Mean urinary total sulforaphane metabolites was 0·08 (sd 0·07) µm/mm creatinine. Total cruciferous vegetable intake was inversely associated with Ki-67 protein expression in breast ductal carcinoma in situ (DCIS) tissue (β=-0·004; se=0·001; FDR q value=0·03), but not in benign or invasive ductal carcinoma (IDC) tissue. No association was found for other biomarkers measured (HDAC3, HDAC6, H3K9, H3K18 and p21) in all tissues examined (benign, DCIS and IDC).
Conclusions
The present study sought to provide additional evidence for the potential role of sulforaphane in histone acetylation and cell proliferation. Here, we report that total cruciferous vegetable intake is associated with decreased cell proliferation in breast DCIS tissue.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
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