Calcium/magnesium intake ratio, but not magnesium intake, interacts with genetic polymorphism in relation to colorectal neoplasia in a two-phase study
Zhu X, Shrubsole MJ, Ness RM, Hibler EA, Cai Q, Long J, Chen Z, Li G, Jiang M, Hou L, Kabagambe EK, Zhang B, Smalley WE, Edwards TL, Giovannucci EL, Zheng W, Zheng W, Dai Q
Molecular carcinogenesis · 13 citations
How it was studied
- Design
- Case-control study (classified by our AI screen)
- Studied in
- People
- Main outcome
- Clinical events such as disease or death
Who paid for it
- Funding
- Independent funding
- Nonprofit
- American Institute for Cancer Research
- University or hospital
- Vanderbilt-Ingram Cancer Center
- Government
- National Cancer Institute
- Government
- National Institute of Diabetes and Digestive and Kidney Diseases
- Government
- National Center for Complementary and Alternative Medicine
- Government
- National Center for Research Resources
- Government
- National Center for Complementary and Integrative Health
- University or hospital
- Vanderbilt Clinical and Translational Research Scholar award
- Unclassified
- Parent studies
- Government
- NCI NIH HHS
- Government
- NIDDK NIH HHS
- Government
- NCCIH NIH HHS
- Government
- NCRR NIH HHS
- Grants
- National Cancer Institute (R01 CA149633); National Cancer Institute (P 30-CA060553); Vanderbilt-Ingram Cancer Center (P30 CA 68485); National Cancer Institute (R25 CA160056); National Institute of Diabetes and Digestive and Kidney Diseases (P30-DK-058404); National Center for Complementary and Integrative Health (R01 AT004660); National Cancer Institute (R01CA121060); National Center for Complementary and Alternative Medicine (R01AT004660); American Institute for Cancer Research (08A074); National Cancer Institute (P30 CA 068485); National Cancer Institute (U01 CA182364); National Center for Research Resources (UL1-RR024975); National Cancer Institute (P50CA095103)
Based on 13 listed funder(s).
Publication
- Published
- 2015-08-31 · Mol Carcinog · vol. 55 · issue 10 · pp. 1449–1457
- Publisher
- Wiley
- Cited
- 18 citations · more than 69% of similar papers · 0.7× the field average
- References
- 57 works
- Access
- Open access (repository copy)
- Research areas
- Magnesium in Health and Disease · Parathyroid Disorders and Treatments · Digestive system and related health
- Keywords
- Colorectal adenoma, Internal medicine, Calcium, Magnesium, Endocrinology, Adenoma, Colorectal cancer, Genotype, Biology, Parathyroid hormone, Gastroenterology, Medicine, Chemistry, Cancer, Genetics, Gene
- MeSH
- humans, colorectal neoplasms, calcium, dietary, magnesium, parathyroid hormone, polymorphism, single nucleotide, adult, aged, middle aged, female, male, trpm cation channels, clinical trials, phase i as topic, clinical trials, phase ii as topic, protein serine-threonine kinases
17 authors
From US
- Xiangzhu ZhuUnited States Department of Veterans Affairs; Vanderbilt University; VA Tennessee Valley Healthcare System; Geriatric Research Education and Clinical Center
- Martha J. ShrubsoleUnited States Department of Veterans Affairs; Vanderbilt University; VA Tennessee Valley Healthcare System; Geriatric Research Education and Clinical Center
- Reid M. NessVanderbilt University
- Elizabeth A. HiblerVanderbilt University
- Qiuyin CaiVanderbilt University
- Jirong LongVanderbilt University
Abstract
Some studies suggest that the calcium to magnesium ratio intakes modify the associations of calcium or magnesium with risk of colorectal adenoma, adenoma recurrence, and cancer. Parathyroid hormone (PTH) plays a key role in the regulation of homeostasis for both calcium and magnesium. We hypothesized that polymorphisms in PTH and 13 other genes may modify the association between the calcium/magnesium intake ratio and colorectal neoplasia risk. We conducted a two-phase study including 1336 cases and 2891 controls from the Tennessee Colorectal Polyp Study. In Phase I, we identified 19 SNPs that significantly interacted with the calcium/magnesium intake ratio in adenoma risk. In Phase II, rs11022858 in PTH was replicated. In combined analysis of phases I and II, we found high calcium/magnesium intake ratio tended to be associated with a reduced risk of colorectal adenoma (P for trend, 0.040) among those who carried the TT genotype in rs11022858. In stratified analyses, calcium intake (≥ 1000 mg/d) was significantly associated with 64% reduced adenoma risk (OR = 0.36 (95% CI : 0.18-0.74)) among those homozygous for the minor allele (TT genotype) (P for trend, 0.012), but not associated with risk in other genotypes (CC/TC). Conversely, we found that highest magnesium intake was significantly associated with 27% reduced risk (OR = 0.73 (95% CI : 0.54-0.97)) of colorectal adenoma (P for trend, 0.026) among those who possessed the CC/TC genotypes, particularly among those with the TC genotype, whereas magnesium intake was not linked to risk among those with the TT genotype. These findings, if confirmed, will help for the development of personalized prevention strategies for colorectal cancer. © 2015 Wiley Periodicals, Inc.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
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