Egg and cholesterol intake and incident type 2 diabetes among French women
Lajous M, Bijon A, Fagherazzi G, Balkau B, Boutron-Ruault MC, Clavel-Chapelon F
The British journal of nutrition · 32 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Cohort study (indexed by PubMed)
- Studied in
- People
- Main outcome
- Clinical events such as disease or death
- Intake measured by
- Food frequency questionnaire
Who paid for it
- Funding
- Independent funding
- Government
- European Commission
- Government
- Agence Nationale de la Recherche
- Government
- Institut National de la Santé et de la Recherche Médicale
- Nonprofit
- Ligue Contre le Cancer
- University or hospital
- Institut Gustave-Roussy
- Nonprofit
- Mutuelle Générale de l'Education Nationale
- Grants
- European Commission (LSHM_CT_2006_037197); Agence Nationale de la Recherche (ANR-10-COHO-0006)
Based on 6 listed funder(s).
Publication
- Published
- 2015-09-10 · Br J Nutr · vol. 114 · issue 10 · pp. 1667–1673
- Publisher
- Cambridge University Press
- Cited
- 42 citations · more than 96% of similar papers · 6.0× the field average
- Impact
- Top 10% most cited in its field
- References
- 20 works
- Access
- Free to read
- Research areas
- Nutritional Studies and Diet · Consumer Attitudes and Food Labeling · Diet and metabolism studies
- Keywords
- Medicine, Hazard ratio, Diabetes mellitus, Prospective cohort study, Proportional hazards model, Cholesterol, Type 2 diabetes, Lower risk, Cohort study, Internal medicine, Menopause, Endocrinology, Confidence interval
- MeSH
- humans, diabetes mellitus, type 2, cholesterol, dietary, diet, risk factors, follow-up studies, prospective studies, eggs, middle aged, france, female
6 authors
From US, FR, MX
- Martín LajousHarvard University; Inserm; Centre de recherche en Epidémiologie et Santé des Populations; Instituto Nacional de Salud Pública
- Anne BijonUniversité Paris-Sud; Inserm; Centre de recherche en Epidémiologie et Santé des Populations
- Guy FagherazziUniversité Paris-Sud; Inserm; Centre de recherche en Epidémiologie et Santé des Populations
- Beverley BalkauUniversité Paris-Sud; Inserm; Centre de recherche en Epidémiologie et Santé des Populations
- Marie‐Christine Boutron‐RuaultUniversité Paris-Sud; Inserm; Centre de recherche en Epidémiologie et Santé des Populations
- Françoise Clavel‐Chapelon · correspondingUniversité Paris-Sud; Inserm; Centre de recherche en Epidémiologie et Santé des Populations
Abstract
Egg consumption is a major source of dietary cholesterol, a nutrient that may disrupt glucose metabolism. We prospectively evaluated the relation between egg consumption and cholesterol-intake and diabetes in 65 364 French disease-free women who responded to a validated diet history questionnaire in 1993. Egg consumption included hardboiled eggs and eggs consumed in an omelette or a mixed dish, and dietary cholesterol was estimated using a French nutrient database. Over 14 years of follow-up, 1803 incident diabetes cases were identified through self-reports, supplementary questionnaires and drug reimbursement information. Multivariable Cox regression models were adjusted for age, education, menopause, menopausal hormone therapy, hypertension and hypercholesterolaemia, BMI, physical activity, smoking, alcohol, fruit, vegetables, processed red meat, coffee and sugar and artificially sweetened beverages. No association was observed between egg consumption and risk of type 2 diabetes. When comparing women who consumed at least five eggs per week with non-consumers, the multivariable hazard ratio (HR) was found to be 1·00 (95 % CI 0·78, 1·29; across categories, P trend=0·11). Women in the highest quintile of dietary cholesterol had a 40 % higher rate of diabetes compared with those in the lowest quintile (HR 1·40; 95 % CI 1·19, 1·63; across quintiles, P trend<0·0001). A 100 mg increase of dietary cholesterol per 4184 kJ (or 1000 kcal) was associated with a 14 % increase in the risk of diabetes (HR 1·14; 95 % CI 1·02, 1·26). In this large prospective cohort, we observed an association between dietary cholesterol and type 2 diabetes, but no association with egg consumption. In the absence of a clear underlying mechanism and potential residual confounding, these results should be interpreted with caution.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
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