Pregnancy-induced changes in the pharmacokinetics of caffeine and its metabolites
Yu T, Campbell SC, Stockmann C, Tak C, Schoen K, Clark EA, Varner MW, Spigarelli MG, Sherwin CM
Journal of clinical pharmacology · 45 citations
How it was studied
- Design
- Controlled clinical trial (indexed by PubMed)
- Studied in
- People
- Main outcome
- Health markers and function
Who paid for it
- Funding
- Independent funding
- University or hospital
- University of Utah
- Government
- National Heart, Lung, and Blood Institute
- Government
- NHLBI NIH HHS
- Nonprofit
- Primary Children Hospital Foundation
- Grants
- National Heart, Lung, and Blood Institute (T35HL007744)
Based on 4 listed funder(s).
Publication
- Published
- 2015-09-11 · J Clin Pharmacol · vol. 56 · issue 5 · pp. 590–596
- Publisher
- Wiley
- Cited
- 69 citations · more than 95% of similar papers · 4.6× the field average
- Impact
- Top 10% most cited in its field
- References
- 33 works
- Access
- Open access (repository copy)
- Research areas
- Pregnancy and Medication Impact · Pharmacogenetics and Drug Metabolism · Coffee research and impacts
- Keywords
- Paraxanthine, Caffeine, Theobromine, Theophylline, Urine, Pharmacokinetics, Metabolite, Pregnancy, CYP1A2, Medicine, Endocrinology, Internal medicine, Pharmacology, Physiology, Metabolism, Chemistry, Biology
- MeSH
- humans, caffeine, theobromine, theophylline, cytochrome p-450 cyp1a2, pregnancy, pregnancy trimesters, adult, female, young adult
9 authors
From US
- Yu TianUniversity of Utah
- Sarah CampbellUniversity of Utah
- Chris R. StockmannUniversity of Utah
- Casey R. TakUniversity of Utah
- Katherine SchoenUniversity of Utah
- Erin ClarkUniversity of Utah
Abstract
This study sought to assess the pharmacokinetic (PK) changes of caffeine and its CYP1A2 metabolites across the 3 trimesters of pregnancy. A prospective, multicenter PK study was conducted among 59 pregnant women (93.2% white) who were studied once during a trimester. One beverage with 30-95 mg caffeine was consumed, and a blood/urine sample was collected within 1 hour postingestion. Concentrations of caffeine and its primary metabolites were quantified from serum and urine by LC-MS/MS. There was a significant increase in dose-normalized caffeine serum and urine concentrations between the first and third trimesters (P < .05 and P < .01, respectively). Normalized theophylline concentrations also increased significantly in the third trimester in serum (P < .001) and in urine (P < .05). The caffeine urine/serum concentration ratio also increased in the last trimester (P < .05). No significant difference was found in normalized paraxanthine or theobromine concentrations. This study identified decreased caffeine metabolism and an increase in the active metabolite theophylline concentrations during pregnancy, especially in the third trimester, revealing evidence of the large role that pregnancy plays in influencing caffeine metabolism.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
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