Funded in part by Nutricia Research Foundation, Nederlandse Zuivel Organisatie, MCO Health, NZO (Dutch Dairy Association)
Dietary Sources of Vitamin B-12 and Their Association with Vitamin B-12 Status Markers in Healthy Older Adults in the B-PROOF Study
Brouwer-Brolsma EM, Dhonukshe-Rutten RA, van Wijngaarden JP, Zwaluw NL, Velde Nv, de Groot LC
Nutrients · 43 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Randomized controlled trial (indexed by PubMed)
- Studied in
- People
- Main outcome
- Health markers and function
- Intake measured by
- Food frequency questionnaire
Who paid for it
- Funding
- Industry funded
- Company
- Nutricia Research Foundation
- Government
- ZonMw
- University or hospital
- Vrije Universiteit Amsterdam
- Industry group
- Nederlandse Zuivel Organisatie
- Government
- Ministerie van Economische Zaken, Landbouw en Innovatie
- University or hospital
- Wageningen University and Research
- Company
- MCO Health
- Industry group
- NZO (Dutch Dairy Association)
- University or hospital
- NCHA (Netherlands Consortium Healthy Ageing)
- Government
- Ministry of Economic Affairs, Agriculture and Innovation
- Government
- The Netherlands Organization for Health Research and Development
- Grants
- ZonMw (6130.0031); Ministerie van Economische Zaken, Landbouw en Innovatie (KB-15-004-003)
Based on 11 listed funder(s) and full-text disclosure statement.
Publication
- Published
- 2015-09-14 · Nutrients · vol. 7 · issue 9 · pp. 7781–7797
- Publisher
- Multidisciplinary Digital Publishing Institute
- Cited
- 60 citations · more than 95% of similar papers · 4.7× the field average
- Impact
- Top 10% most cited in its field
- References
- 22 works
- Access
- Open access (journal) · CC-BY
- Research areas
- Folate and B Vitamins Research · Nutritional Studies and Diet · Child Nutrition and Feeding Issues
- Keywords
- Vitamin, Vitamin D and neurology, Medicine, Malabsorption, Shellfish, Food science, Biology, Physiology, Animal science, Internal medicine, Fish <Actinopterygii>, Aquatic animal
- MeSH
- animals, fishes, humans, vitamin b deficiency, vitamin b 12, diet, nutrition assessment, prevalence, cross-sectional studies, age factors, sex factors, nutritional status, aging, dairy products, eggs, meat, seafood, shellfish, aged, netherlands, female, male, biomarkers, surveys and questionnaires
6 authors
From NL
- Elske Maria Brouwer-Brolsma · correspondingWageningen University & Research
- R.A.M. Dhonukshe-RuttenWageningen University & Research
- Janneke van WijngaardenWageningen University & Research
- Nikita van der ZwaluwWageningen University & Research
- Nathalie van der VeldeErasmus MC; Amsterdam UMC Location University of Amsterdam; Erasmus University Rotterdam
- C.P.G.M. de GrootWageningen University & Research
Abstract
Low vitamin B-12 concentrations are frequently observed among older adults. Malabsorption is hypothesized to be an important cause of vitamin B-12 inadequacy, but serum vitamin B-12 may also be differently affected by vitamin B-12 intake depending on food source. We examined associations between dietary sources of vitamin B-12 (meat, fish and shellfish, eggs, dairy) and serum vitamin B-12, using cross-sectional data of 600 Dutch community-dwelling adults (≥65 years). Dietary intake was assessed with a validated food frequency questionnaire. Vitamin B-12 concentrations were measured in serum. Associations were studied over tertiles of vitamin B-12 intake using P for trend, by calculating prevalence ratios (PRs), and splines. Whereas men had significantly higher vitamin B-12 intakes than women (median (25th-75th percentile): 4.18 (3.29-5.38) versus 3.47 (2.64-4.40) μg/day), serum vitamin B-12 did not differ between the two sexes (mean ± standard deviation (SD): 275 ± 104 pmol/L versus 290 ± 113 pmol/L). Higher intakes of dairy, meat, and fish and shellfish were significantly associated with higher serum vitamin B-12 concentrations, where meat and dairy-predominantly milk were the most potent sources. Egg intake did not significantly contribute to higher serum vitamin B-12 concentrations. Thus, dairy and meat were the most important contributors to serum vitamin B-12, followed by fish and shellfish.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
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