Linoleic acid and breast cancer risk: a meta-analysis
Zhou Y, Wang T, Zhai S, Li W, Meng Q
Public health nutrition · 41 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Meta-analysis (indexed by PubMed)
- Studied in
- People
- Main outcome
- Clinical events such as disease or death
- Intake measured by
- Not stated
Who paid for it
- Funding
- Funding not disclosed
Publication
- Published
- 2015-10-05 · Public Health Nutr · vol. 19 · issue 8 · pp. 1457–1463
- Publisher
- Cambridge University Press
- Cited
- 66 citations · more than 43% of similar papers · 0.2× the field average
- References
- 35 works
- Access
- Free to read
- Research areas
- Fatty Acid Research and Health · Cancer, Lipids, and Metabolism · Antioxidant Activity and Oxidative Stress
- Keywords
- Linoleic acid, Breast cancer, Medicine, Prospective cohort study, Internal medicine, Relative risk, Meta-analysis, Cohort study, Lower risk, Cancer, Conjugated linoleic acid, Fatty acid, Endocrinology, Gastroenterology, Chemistry, Confidence interval, Biochemistry
- MeSH
- humans, breast neoplasms, linoleic acid, diet, risk factors, female
5 authors
From CN
- Yunping ZhouThe Fourth People's Hospital of Zibo City; Shandong Center for Disease Control and Prevention
- Tao WangThe Fourth People's Hospital of Zibo City; Shandong Center for Disease Control and Prevention
- Shenyong ZhaiThe Fourth People's Hospital of Zibo City; Shandong Center for Disease Control and Prevention
- Wei LiThe Fourth People's Hospital of Zibo City; Shandong Center for Disease Control and Prevention
- Qiang Meng · correspondingThe Fourth People's Hospital of Zibo City; Shandong Center for Disease Control and Prevention
Abstract
Objective
Prior studies on linoleic acid, the predominant n-6 fatty acid, and breast cancer risk have generated inconsistent results. We performed a meta-analysis to summarize the evidence regarding the relationship of dietary and serum linoleic acid with breast cancer risk.
Design
Pertinent studies were identified by a search of PubMed and EMBASE. The fixed- or random-effect pooled measure was selected based on between-study heterogeneity.
Results
Eight prospective cohort studies and four prospective nested case-control studies, involving 10 410 breast cancer events from 358 955 adult females across different countries, were included in present study. Compared with the lowest level of linoleic acid, the pooled relative risk (RR; 95 % CI) of breast cancer was 0·98 (0·93, 1·04) for the highest level of linoleic acid. The pooled RR (95 % CI) for dietary and serum linoleic acid were 0·99 (0·92, 1·06) and 0·98 (0·88, 1·08), respectively. The RR (95 % CI) of breast cancer was 0·97 (0·91, 1·04), 0·95 (0·85, 1·07), 0·96 (0·86, 1·07), 0·98 (0·87, 1·10) and 0·99 (0·85, 1·14) for linoleic acid intake of 5, 10, 15, 20 and 25 g/d, respectively. The risk of breast cancer decreased by 1 % (RR=0·99; 95 % CI 0·93, 1·05) for every 10 g/d increment in linoleic acid intake.
Conclusions
This meta-analysis indicated that both dietary linoleic acid intake and serum linoleic acid level were associated with decreased risk of breast cancer, although none of the associations were statistically significant. Further investigations are warranted.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
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