Serum Ferritin Is Associated with Metabolic Syndrome and Red Meat Consumption
Avila F, Echeverría G, Pérez D, Martinez C, Strobel P, Castillo O, Villaroel L, Mezzano D, Rozowski J, Urquiaga I, Leighton F
Oxidative medicine and cellular longevity · 27 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Randomized controlled trial (indexed by PubMed)
- Studied in
- People
- Main outcome
- Health markers and function
- Intake measured by
- Food diaries or recalls
Who paid for it
- Funding
- Independent funding
- University or hospital
- Pontificia Universidad Católica de Chile
- University or hospital
- Universidad de Talca
- University or hospital
- Center for Molecular Nutrition and Chronic Diseases, Pontificia Universidad Católica de Chile
Based on 3 listed funder(s) and full-text disclosure statement.
Publication
- Published
- 2015-01-01 · Oxid Med Cell Longev · vol. 2015 · pp. 1–8
- Publisher
- Hindawi Publishing Corporation
- Cited
- 51 citations · more than 90% of similar papers · 2.6× the field average
- References
- 32 works
- Access
- Open access (hybrid journal) · CC-BY
- Research areas
- Iron Metabolism and Disorders · Folate and B Vitamins Research · Trace Elements in Health
- Keywords
- Metabolic syndrome, Ferritin, Glycated hemoglobin, Internal medicine, Insulin resistance, Medicine, Diabetes mellitus, Red meat, Hemoglobin, Endocrinology, Physiology, Insulin, Oxidative stress, Type 2 diabetes, Pathology
- MeSH
- humans, risk factors, adult, male, ferritins, red meat, metabolic syndrome
11 authors
From CL
- Felipe Alberto Gómez ÁvilaUniversity of Talca; Pontificia Universidad Católica de Chile
- Guadalupe EcheverríaPontificia Universidad Católica de Chile
- Druso PérezPontificia Universidad Católica de Chile
- Martinez CarlosPontificia Universidad Católica de Chile
- Pablo StrobelPontificia Universidad Católica de Chile
- Oscar A. CastilloPontificia Universidad Católica de Chile
Abstract
Background and aims
Hyperferritinemia has been related with a wide spectrum of pathologies, including diabetes, cardiovascular disease, neurodegenerative disorders, and metabolic syndrome. The aim of this study was to investigate the association between hyperferritinemia and iron consumption.
Methods and results
Serum ferritin concentration was evaluated in 66 presumed healthy men, along with other clinical and biochemical markers of chronic diseases. A three-day food questionnaire was applied for nutrition information. Hyperferritinemia was a condition found in 13.4% of the volunteers analyzed. Significant correlations were found between serum ferritin concentration and metabolic syndrome parameters (HDL cholesterol, triglycerides, and fasting glucose) as well as an increase of the serum ferritin mean value with the number of risk factors of metabolic syndrome. Also, oxidative stress markers (carbonyl groups, AOPP, and glycated hemoglobin), hepatic damage markers (GGT, SGOT), and parameters related to insulin resistance (HOMA, blood insulin, and blood glucose) correlate significantly with serum ferritin. Volunteers had an excessive iron intake, principally by bread consumption. Analyses of food intake showed that red meat consumption correlates significantly with serum ferritin.
Conclusion
Red meat consumption, metabolic syndrome, and chronic disease markers are associated with hyperferritinemia in a population of Chilean men.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
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