Visible Light-Induced Lipid Peroxidation of Unsaturated Fatty Acids in the Retina and the Inhibitory Effects of Blueberry Polyphenols
Liu Y, Zhang D, Hu J, Liu G, Chen J, Sun L, Jiang Z, Zhang X, Chen Q, Ji B
Journal of agricultural and food chemistry · 26 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- In vitro/mechanistic study (classified by our AI screen)
- Studied in
- People, plus animal or lab work
- Main outcome
- Mechanisms only
Who paid for it
- Funding
- Independent funding
- Government
- National Natural Science Foundation of China
- Government
- National Key Technology R&D Program for the twelfth 5-year plan
- Grants
- National Natural Science Foundation of China (project no. 31571831)
Based on 2 listed funder(s).
Publication
- Published
- 2015-10-12 · J Agric Food Chem · vol. 63 · issue 42 · pp. 9295–9305
- Publisher
- American Chemical Society
- Cited
- 44 citations · more than 91% of similar papers · 2.9× the field average
- Impact
- Top 10% most cited in its field
- References
- 42 works
- Access
- Paywalled
- Research areas
- Retinal Diseases and Treatments · Antioxidant Activity and Oxidative Stress · Retinal Development and Disorders
- Keywords
- Lipid peroxidation, Docosahexaenoic acid, Retinal, Polyphenol, Biochemistry, Arachidonic acid, Chemistry, Anthocyanin, Flavonoid, Antioxidant, Retina, Fatty acid, Polyunsaturated fatty acid, Food science, Biology, Enzyme
- MeSH
- retina, animals, rabbits, humans, retinal diseases, fatty acids, unsaturated, plant extracts, lipid peroxidation, light, dietary supplements, polyphenols, blueberry plants
10 authors
From CN
- Yixiang LiuJimei University
- Di ZhangJiangsu University
- Jimei HuChina Agricultural University
- Guangming LiuJimei University
- Jun ChenJimei University
- Le‐Chang SunJimei University
Abstract
The lipid peroxidation of unsaturated fatty acids (UFAs) in the retina not only threatens visual cells but also affects the physiological health of the retina. In this work, the potential damages caused by daily visible light exposure on retinal UFAs were evaluated via a simulated in vitro model. At the same time, the benefits of dietary supplementation of blueberries to the eyes were also assessed. After prolonged light exposure, lipid peroxidation occurred for both docosahexaenoic and arachidonic acids (DHA and AA, respectively). The oxidized UFAs presented obvious cytotoxicity and significantly inhibited cell growth in retinal pigment epithelium cells. Among the different blueberry polyphenol fractions, the flavonoid-rich fraction, in which quercetin was discovered as the main component, was considerably better in preventing visible light-induced DHA lipid peroxidation than the anthocyanin- and phenolic acid-rich fractions. Then the retinal protective activity of blueberry polyphenols against light-induced retinal injury was confirmed in vivo. On the basis of the above results, inhibiting lipid peroxidation of UFAs in the retina is proposed to be another important function mechanism for antioxidants to nourish eyes.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
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