Comparative trial of Aloe vera/olive oil combination cream versus phenytoin cream in the treatment of chronic wounds
Panahi Y, Izadi M, Sayyadi N, Rezaee R, Jonaidi-Jafari N, Beiraghdar F, Zamani A, Sahebkar A
Journal of wound care · 33 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Randomized controlled trial (indexed by PubMed)
- Studied in
- People
- Main outcome
- Health markers and function
- Intake measured by
- Not stated
Who paid for it
- Funding
- Funding not disclosed
Publication
- Published
- 2015-10-02 · J Wound Care · vol. 24 · issue 10 · pp. 459–465
- Publisher
- Mark Allen Group
- Cited
- 60 citations · more than 94% of similar papers · 4.5× the field average
- Impact
- Top 10% most cited in its field
- References
- 37 works
- Access
- Paywalled
- Research areas
- Wound Healing and Treatments · Phytochemistry and biological activity of medicinal plants · Pressure Ulcer Prevention and Management
- Keywords
- Medicine, Aloe vera, Visual analogue scale, Wound healing, Randomized controlled trial, Surgery, Traditional medicine
- MeSH
- humans, aloe, pain, wounds and injuries, chronic disease, phenytoin, plant preparations, anti-infective agents, pain measurement, treatment outcome, phytotherapy, drug therapy, combination, double-blind method, wound healing, olive oil
8 authors
From IR, AU
- Yunes PanahiBaqiyatallah University of Medical Sciences
- Morteza IzadiBaqiyatallah University of Medical Sciences
- N. SayyadiIslamic Azad University Pharmaceutical Sciences Branch
- Ramin RezaeeNorth Khorasan University of Medical Sciences
- Nematollah Jonaidi JafariBaqiyatallah University of Medical Sciences
- Fatemeh BeiraghdarBaqiyatallah University of Medical Sciences
Abstract
Objective
Aloe vera is a medicinal plant that has been traditionally used to accelerate wound healing. Olive oil is also a natural product that may contribute to wound healing owing to its antimicrobial and anti-inflammatory effects. The present study aimed to evaluate the effect of an Aloe vera-olive oil (AVO) combination cream on the healing process of chronic wounds.
Method
In this randomised, double-blind, comparator-controlled, parallel-group trial, patients with chronic wounds were treated with either AVO cream or phenytoin cream as the standard treatment for a period of 30 days. Wound healing was evaluated using Bates-Jensen assessment tool and the severity of pain was assessed using a visual analogue scale (VAS).
Results
After initial assessment, 60 patients with chronic wounds (41 with pressure ulcer, 13 with diabetic wounds and 6 with venous ulcers), were recruited and randomised into 2 groups of 30. After 30 days of treatment, significant improvements in the wound size, depth, and edges; necrotic tissue type and amount; exudate type and amount; colour of wound surroundings; and peripheral tissue oedema score were observed in the AVO cream group (p<0.001). The total score of wound healing showed significant improvement with both AVO (p<0.001) and phenytoin (p<0.01) creams, although AVO was more efficacious (p<0.001). Likewise, although both treatments reduced the initial VAS score, the efficacy of AVO was significantly greater (p<0.001).
Conclusion
AVO cream significantly accelerates biological healing of chronic wounds and helps to reduce pain severity with a higher efficacy compared with phenytoin cream.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
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