Sulforaphane Bioavailability and Chemopreventive Activity in Women Scheduled for Breast Biopsy
Atwell LL, Zhang Z, Mori M, Farris P, Vetto JT, Naik AM, Oh KY, Thuillier P, Ho E, Shannon J
Cancer prevention research (Philadelphia, Pa.) · 98 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Randomized controlled trial (indexed by PubMed)
- Studied in
- People
- Main outcome
- Mechanisms only
- Intake measured by
- Intake biomarkers
Who paid for it
- Funding
- Independent funding
- Government
- National Cancer Institute
- Government
- National Institute of Environmental Health Sciences
- Government
- National Center for Advancing Translational Sciences
- Government
- NCI NIH HHS
- Government
- NIEHS NIH HHS
- Government
- NCATS NIH HHS
- Grants
- National Cancer Institute (P30 CA-069533); National Institute of Environmental Health Sciences (P30ES000210); National Center for Advancing Translational Sciences (UL1TR000128); National Cancer Institute (R21 CA132236-01A2); National Cancer Institute (P01 CA090890); National Cancer Institute (R21 CA132236)
Based on 6 listed funder(s).
Publication
- Published
- 2015-10-28 · Cancer Prev Res (Phila) · vol. 8 · issue 12 · pp. 1184–1191
- Publisher
- American Association for Cancer Research
- Cited
- 125 citations · more than 92% of similar papers · 3.0× the field average
- Impact
- Top 10% most cited in its field
- References
- 55 works
- Access
- Open access (repository copy)
- Research areas
- Genomics, phytochemicals, and oxidative stress · Histone Deacetylase Inhibitors Research · Family Support in Illness
- Keywords
- Sulforaphane, Medicine, Breast cancer, Ductal carcinoma, Internal medicine, Oncology, Glucoraphanin, Biopsy, Cancer, Cancer research, Biology
- MeSH
- humans, carcinoma, intraductal, noninfiltrating, breast neoplasms, isothiocyanates, sulfoxides, anticarcinogenic agents, chemoprevention, immunohistochemistry, double-blind method, biological availability, dietary supplements, female, mass spectrometry, biomarkers, tumor
10 authors
From US
- Lauren L. AtwellOregon State University; California State University, Chico
- Zhenzhen ZhangOregon Health & Science University
- Motomi MoriOregon Health & Science University
- Paige E. FarrisOregon Health & Science University
- John T. VettoOregon Health & Science University
- Arpana M. NaikOregon Health & Science University
Abstract
Epidemiologic studies suggest a protective effect of cruciferous vegetables on breast cancer. Sulforaphane (SFN), an active food component derived from crucifers, has been shown to be effective in breast cancer chemoprevention. This study evaluated the chemopreventive effect of SFN on selective biomarkers from blood and breast tissues. In a 2- to 8-week double-blinded, randomized controlled trial, 54 women with abnormal mammograms and scheduled for breast biopsy were randomized to consume a placebo or a glucoraphanin (GFN) supplement providing SFN (n = 27). Plasma and urinary SFN metabolites, peripheral blood mononuclear cell (PBMC) histone deacetylase (HDAC) activity, and tissue biomarkers (H3K18ac, H3K9ac, HDAC3, HDAC6, Ki-67, p21) were measured before and after the intervention in benign, ductal carcinoma in situ, or invasive ductal carcinoma breast tissues. Within the supplement group, Ki-67 (P = 0.003) and HDAC3 (P = 0.044) levels significantly decreased in benign tissue. Pre-to-postintervention changes in these biomarkers were not significantly different between treatment groups after multiple comparison adjustment. GFN supplementation was associated with a significant decrease in PBMC HDAC activity (P = 0.04). No significant associations were observed between SFN and examined tissue biomarkers when comparing treatment groups. This study provides evidence that GFN supplementation for a few weeks is safe but may not be sufficient for producing changes in breast tissue tumor biomarkers. Future studies employing larger sample sizes should evaluate alternative dosing and duration regimens to inform dietary SFN strategies in breast cancer chemoprevention.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
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