Comparison of Low-Level Laser Therapy versus Ozone Therapy in the Treatment of Oral Lichen Planus
Kazancioglu HO, Erisen M
Annals of dermatology · 46 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Randomized controlled trial (classified by our AI screen)
- Studied in
- People
- Main outcome
- Health markers and function
Who paid for it
- Funding
- Funding not disclosed
Publication
- Published
- 2015-01-01 · Ann Dermatol · vol. 27 · issue 5 · p. 485
- Publisher
- Korean Dermatological Association
- Cited
- 75 citations · more than 96% of similar papers · 5.1× the field average
- Impact
- Top 10% most cited in its field
- References
- 37 works
- Access
- Open access (hybrid journal) · CC-BY-NC
- Research areas
- Oral Health Pathology and Treatment · Laser Applications in Dentistry and Medicine · Medical and Biological Ozone Research
- Keywords
- Medicine, Oral lichen planus, Corticosteroid, Ozone therapy, Placebo, Dermatology, Internal medicine, Low level laser therapy, Gastroenterology, Surgery, Laser therapy, Pathology
2 authors
From TR
- Hakkı Oğuz KazancioğluBezmiâlem Vakıf Üniversitesi
- Merve ErisenIstanbul University
Abstract
Background
The treatment options for oral lichen planus (OLP) are numerous and include topical and systemic agents. Intralesional and systemic corticosteroids are used; however, the therapeutic results are often disappointing.
Objective
To compare the influence of ozone, laser, and topical corticosteroid therapies in the treatment of OLP.
Methods
One hundred twenty adult patients with ≤3 cm atrophic-erosive biopsy-proven OLPs in the tongue or buccal mucosa were recruited into the study. They were randomly assigned, by preoperative envelope drawing, to be treated with low-level laser therapy (LLLT group), ozone therapy (ozonated group), and topical corticosteroid therapy (positive control group). A placebo treatment containing base ointment without the active corticosteroid component was administered to patients in the negative control group. Response rate scores were determined on the basis of changes in the appearance score and pain score of the lesions between baseline and after each treatment.
Results
The study subjects consisted of 56 male and 64 female OLP patients with a combined mean age of 42.6±8.3 years (range, 28~55 years). No statistically significant difference was detected in clinical severity among the groups. The sign scores decreased in almost all scoring groups; however, statistically significant improvement was found in the ozonated and corticosteroid-treated groups. Symptom improvement was achieved after treatment with LLLT, ozone, and corticosteroid (p<0.05). The efficacy indices were significantly higher in the ozonated and corticosteroid-treated groups.
Conclusion
Ozone and corticosteroid therapies were more effective than 808-nm LLLT in the treatment of OLP.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY-NC).
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