Association between Dietary Magnesium Intake and Hyperuricemia
Wang YL, Zeng C, Wei J, Yang T, Li H, Deng ZH, Yang Y, Zhang Y, Ding X, Xie DX, Yang TB, Lei GH
PloS one · 13 citations
How it was studied
- Design
- Controlled clinical trial (indexed by PubMed)
- Studied in
- People
- Main outcome
- Health markers and function
Who paid for it
- Funding
- Independent funding
- Government
- Development and Reform Commission of Hunan Province
- Government
- National Natural Science Foundation of China
- Government
- Ministry of Education of the People's Republic of China
- University or hospital
- Central South University
- Government
- Hunan Provincial Innovation Foundation for Postgraduate
- Government
- Fundamental Research Funds for the Central Universities
- Grants
- National Natural Science Foundation of China (No. 81201420, 81272034); National Natural Science Foundation of China (No. 81201420); Hunan Provincial Innovation Foundation for Postgraduate (81472130); Development and Reform Commission of Hunan Province (81472130); Development and Reform Commission of Hunan Province (81272034); National Natural Science Foundation of China (81201420); Central South University (81472130); Ministry of Education of the People's Republic of China (20120162110036); National Natural Science Foundation of China (81272034); Central South University (81272034); National Natural Science Foundation of China (NO. 81201420, 81272034, 81472130); National Natural Science Foundation of China (14JJ3032); Central South University (14JJ3032); Development and Reform Commission of Hunan Province (14JJ3032); Hunan Provincial Innovation Foundation for Postgraduate (CX2014A005); Hunan Provincial Innovation Foundation for Postgraduate (14JJ3032); Hunan Provincial Innovation Foundation for Postgraduate (81272034); National Natural Science Foundation of China (2013SK2018); National Natural Science Foundation of China (81201420, 81272034, 81472130); National Natural Science Foundation of China (81472130)
Based on 6 listed funder(s) and full-text disclosure statement.
Publication
- Published
- 2015-11-04 · PLoS One · vol. 10 · issue 11 · p. e0141079
- Publisher
- Public Library of Science
- Cited
- 23 citations · more than 81% of similar papers · 1.5× the field average
- References
- 59 works
- Access
- Open access (journal) · CC-BY
- Research areas
- Gout, Hyperuricemia, Uric Acid · Magnesium in Health and Disease · Diet, Metabolism, and Disease
- Keywords
- Hyperuricemia, Magnesium, Medicine, Association (psychology), Endocrinology, Internal medicine, Physiology, Chemistry, Uric acid, Psychology
- MeSH
- humans, hyperuricemia, magnesium, cross-sectional studies, sex characteristics, dietary supplements, aged, middle aged, female, male
12 authors
From CN
- Yilun WangCentral South University; Xiangya Hospital Central South University
- Chao ZengCentral South University; Xiangya Hospital Central South University
- Jie WeiCentral South University
- Tuo YangCentral South University; Xiangya Hospital Central South University
- Hui LiCentral South University; Xiangya Hospital Central South University
- Zhenhan DengCentral South University; Xiangya Hospital Central South University
Abstract
Objective
To examine the cross-sectional associations between dietary magnesium (Mg) intake and hyperuricemia (HU).
Methods
5168 subjects were included in this study. Dietary intake was assessed using a validated semi-quantitative food frequency questionnaire. Hyperuricemia (HU) was defined as uric acid ≥ 416 μmol/L for male population and ≥ 360 μmol/L for female. A multivariable logistic analysis model was applied to test the associations after adjusting a number of potential confounding factors.
Results
The relative odds of the overall prevalence of HU were decreased by 0.57 times in the fourth quintile of Mg intake (OR 0.57, 95% CI 0.35-0.94) and 0.55 times in the fifth quintile (OR 0.55, 95% CI 0.30-1.01) comparing with the lowest quintile, and P for trend was 0.091. The results of multivariable linear regression also suggested a significant inverse association between serum uric acid and Mg intake (β = -0.028, P = 0.022). For male, the relative odds of HU were decreased by 0.62 times in the third quintile of Mg intake (OR 0.62, 95% CI 0.40-0.97), 0.40 times in the fourth quintile (OR 0.40, 95% CI 0.23-0.72) and 0.35 times in the fifth quintile (OR 0.35, 95% CI 0.17-0.71) comparing with the lowest quintile, and P for trend was 0.006. Multivariable adjusted inverse association was also existed between serum uric acid and Mg intake in male population (β = -0.061, P = 0.002). However, no significant association was observed between dietary Mg intake and HU for female.
Conclusions
The findings of this cross-sectional study indicated that dietary Mg intake is inversely associated with HU, independent of some major confounding factors. In addition, this association remains valid for the male subgroup, but not for the female subgroup.
Level of evidence
LevelIII, cross-sectional study.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
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