Haemaphysalis longicornis tick bites are a possible cause of red meat allergy in Japan
Chinuki Y, Ishiwata K, Yamaji K, Takahashi H, Morita E
Allergy · 98 citations
How it was studied
- Design
- In vitro/mechanistic study (classified by our AI screen)
- Studied in
- People, plus animal or lab work
- Main outcome
- Health markers and function
- Intake measured by
- Not stated
Who paid for it
- Funding
- Independent funding
- University or hospital
- Shimane University
- University or hospital
- Universitätsklinikum Tübingen
- Government
- JSPS KAKENHI
- Unclassified
- Practical Research Project
Based on 4 listed funder(s).
Publication
- Published
- 2015-11-09 · Allergy · vol. 71 · issue 3 · pp. 421–425
- Publisher
- Wiley
- Cited
- 135 citations · more than 98% of similar papers · 6.9× the field average
- Impact
- Top 10% most cited in its field
- References
- 12 works
- Access
- Paywalled
- Research areas
- Vector-borne infectious diseases · Food Allergy and Anaphylaxis Research · Vector-Borne Animal Diseases
- Keywords
- Haemaphysalis longicornis, Tick, Amblyomma americanum, Biology, Allergy, Immunoglobulin E, Immunology, Saliva, Food allergy, Microbiology, Antibody, Virology, Ixodidae, Biochemistry
- MeSH
- animals, humans, ixodes, food hypersensitivity, galactose, immunoglobulin e, allergens, geography, adult, aged, aged, 80 and over, middle aged, japan, female, male, tick bites, red meat
5 authors
From JP
- Yuko Chinuki · correspondingShimane University
- Kenji IshiwataJikei University School of Medicine
- Katsuhiko YamajiJikei University School of Medicine
- Hitoshi TakahashiShimane University
- Eishin MoritaShimane University
Abstract
Recent studies revealed that Amblyomma or Ixodes tick bites may cause red meat allergy, in which galactose-α-1,3-galactose (α-Gal) is a major IgE-binding epitope. The incidence of red meat allergy is high in Shimane Prefecture, as is tick-transmitted Japanese spotted fever. Therefore, we speculated that tick bites may cause these meat allergies. The carbohydrate α-Gal was detected in the salivary gland protein of Haemaphysalis longicornis (H. longicornis), the vector for Japanese spotted fever, by immunoblotting using anti-α-Gal antibody. H. longicornis salivary gland protein-specific IgE was detected in the sera of 24 of 30 patients with red meat allergies. Sensitization to tick salivary gland protein containing α-Gal is possibly a major etiology of red meat allergy; the carbohydrate plays a crucial role in its allergenicity. These results further indicate that the α-Gal epitope is present not only in Amblyomma or Ixodes, but also in Haemaphysalis.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
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