Olive Oil, Sunflower Oil or no Oil for Baby Dry Skin or Massage: A Pilot, Assessor-blinded, Randomized Controlled Trial (the Oil in Baby SkincaRE [OBSeRvE] Study)
Cooke A, Cork MJ, Victor S, Campbell M, Danby S, Chittock J, Lavender T
Acta dermato-venereologica · 42 citations
How it was studied
- Design
- Randomized controlled trial (indexed by PubMed)
- Studied in
- People
- Main outcome
- Health markers and function
Who paid for it
- Funding
- Independent funding
- Government
- National Institute for Health and Care Research
- Government
- National Institute for Health Research (NIHR)
- Grants
- National Institute for Health and Care Research (DRF-2012-05-160)
Based on 2 listed funder(s).
Publication
- Published
- 2015-11-09 · Acta Derm Venereol · vol. 96 · issue 3 · pp. 323–330
- Publisher
- Soc for Publication of Acta Dermato-Venereologica
- Cited
- 72 citations · more than 99% of similar papers · 13.4× the field average
- Impact
- Top 10% most cited in its field
- References
- 52 works
- Access
- Open access (journal) · CC-BY-NC
- Research areas
- Neonatal skin health care · Dermatology and Skin Diseases · Advancements in Transdermal Drug Delivery
- Keywords
- Medicine, Transepidermal water loss, Sunflower oil, Randomized controlled trial, Atopic dermatitis, Dry skin, Erythema, Stratum corneum, Clinical trial, Massage, Dermatology, Surgery, Internal medicine, Pathology
- MeSH
- skin, humans, erythema, plant oils, emollients, treatment outcome, massage, administration, cutaneous, pilot projects, water loss, insensible, hydrogen-ion concentration, time factors, infant, newborn, england, medication adherence, olive oil, sunflower oil
7 authors
From GB
- Alison Cooke · correspondingUniversity of Manchester
- Michael J. Cork
- Suresh Victor · correspondingUniversity of Manchester
- Malcolm Campbell
- Simon G. Danby · correspondingUniversity of Manchester
- John Chittock
Abstract
Topical oils on baby skin may contribute to development of childhood atopic eczema. A pilot, assessor-blinded, randomized controlled trial assessed feasibility of a definitive trial investigating their impact in neonates. One-hundred and fifteen healthy, full-term neonates were randomly assigned to olive oil, sunflower oil or no oil, twice daily for 4 weeks, stratified by family history of atopic eczema. We measured spectral profile of lipid lamellae, trans-epidermal water loss (TEWL), stratum corneum hydration and pH and recorded clinical observations, at baseline, and 4 weeks post-birth. Recruitment was challenging (recruitment 11.1%; retention 80%), protocol adherence reasonable (79-100%). Both oil groups had significantly improved hydration but significantly less improvement in lipid lamellae structure compared to the no oil group. There were no significant differences in TEWL, pH or erythema/skin scores. The study was not powered for clinical significance, but until further research is conducted, caution should be exercised when recommending oils for neonatal skin.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
Community trust
Loading…
How much do you trust this study's findings?
Comments
Sign in to rate, comment on or flag this study.Sign inSomething wrong here?
Flag this study if its information, labels or funding look wrong. An editor reviews every flag.
Sign in to rate, comment on or flag this study.Sign inEducational information about published research. Not medical advice, and not a recommendation to start or stop anything.