Magnesium intake and incidence of pancreatic cancer: the VITamins and Lifestyle study
Dibaba D, Xun P, Yokota K, White E, He K
British journal of cancer · 26 citations
How it was studied
- Design
- Cohort study (indexed by PubMed)
- Studied in
- People
- Main outcome
- Clinical events such as disease or death
Who paid for it
- Funding
- Independent funding
- Government
- Office of Dietary Supplements
- Government
- National Cancer Institute
- Government
- NCI NIH HHS
- Grants
- National Cancer Institute (P30 CA 015704); National Cancer Institute (K05-CA154337); National Cancer Institute (R03 CA139261)
Based on 3 listed funder(s) and full-text disclosure statement.
Publication
- Published
- 2015-11-10 · Br J Cancer · vol. 113 · issue 11 · pp. 1615–1621
- Publisher
- Springer Nature
- Cited
- 39 citations · more than 80% of similar papers · 1.4× the field average
- References
- 53 works
- Access
- Open access (hybrid journal) · CC-BY-NC-SA
- Research areas
- Magnesium in Health and Disease · Parathyroid Disorders and Treatments · Pancreatitis Pathology and Treatment
- Keywords
- Pancreatic cancer, Incidence (geometry), Medicine, Internal medicine, Cancer, Endocrinology, Physiology, Gastroenterology
- MeSH
- humans, pancreatic neoplasms, magnesium, incidence, proportional hazards models, longitudinal studies, prospective studies, eating, aged, middle aged, washington, female, male, recommended dietary allowances
5 authors
From US, JP
- Daniel Tefera DibabaIndiana University Bloomington
- Pengcheng XunIndiana University Bloomington
- Kuninobu YokotaJikei University School of Medicine
- Emily D. WhiteUniversity of Washington; Fred Hutch Cancer Center
- Ka He · correspondingIndiana University Bloomington
Abstract
Background
Studies document that magnesium is inversely associated with the risk of diabetes, which is a risk factor of pancreatic cancer. However, studies on the direct association of magnesium with pancreatic cancer are few and findings are inconclusive. In this study, we aimed to investigate the longitudinal association between magnesium intake and pancreatic cancer incidence in a large prospective cohort study.
Method
A cohort of 66,806 men and women aged 50-76 years at baseline who participated in the VITamins And Lifestyle (VITAL) study was followed from 2000 to 2008. Multivariable-adjusted Cox regression models were used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) of pancreatic cancer incidence by magnesium intake categories.
Result
During an average of 6.8-year follow-up, 151 participants developed pancreatic cancer. Compared with those who met the recommended dietary allowance (RDA) for magnesium intake, the multivariable-adjusted HRs (95% CIs) for pancreatic cancer were 1.42 (0.91, 2.21) for those with magnesium intake in the range of 75-99% RDA and 1.76 (1.04, 2.96) for those with magnesium intake <75% RDA. Every 100 mg per day decrement in magnesium intake was associated with a 24% increase in the incidence of pancreatic cancer (HR: 1.24; 95% CI: 1.02, 1.50; P(trend)=0.03). The observed inverse associations appeared not to be appreciably modified by age, gender, body mass index, and non-steroidal anti-inflammatory drug use but appeared to be limited to those taking magnesium supplementation (from multivitamins or individual supplement).
Conclusions
Findings from this prospective cohort study indicate that magnesium intake may be beneficial in terms of primary prevention of pancreatic cancer.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY-NC-SA).
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