Mobilization of Bone Marrow-Derived Endothelial Progenitor Cells following Finnish Sauna: A Pilot Study
Donndorf P, Lube L, Lux C, Skorska A, Steinhoff G, Kraft K
Forschende Komplementarmedizin (2006) · 4 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Controlled clinical trial (classified by our AI screen)
- Studied in
- People
- Main outcome
- Mechanisms only
Who paid for it
- Funding
- Funding not disclosed
Publication
- Published
- 2015-01-01 · Forsch Komplementmed · vol. 22 · issue 4 · pp. 246–250
- Publisher
- Karger Publishers
- Cited
- 7 citations · more than 77% of similar papers · 1.1× the field average
- References
- 17 works
- Access
- Paywalled
- Research areas
- Thermoregulation and physiological responses · Skin Protection and Aging · Hair Growth and Disorders
- Keywords
- Medicine, CD34, Progenitor cell, Bone marrow, Peripheral blood mononuclear cell, Endothelial progenitor cell, Andrology, Stem cell, Immunology, Internal medicine, Biology, In vitro, Biochemistry
- MeSH
- humans, antigens, cd, steam bath, flow cytometry, cell movement, adult, male, hemodynamics, young adult, endothelial progenitor cells
6 authors
From DE
- Peter DonndorfUniversity of Rostock
- Luisa LubeUniversity of Rostock
- Cornelia Aquilina LuxUniversity of Rostock
- Anna SkorskaUniversity of Rostock
- Gustav SteinhoffUniversity of Rostock
- Karin KraftUniversity of Rostock
Abstract
Background
Sauna bathing is claimed to provide benefits for patients suffering from cardiovascular diseases. The current study aims at analyzing the induction of potential regenerative processes by quantifying the mobilization of bone marrow-derived stem cells into the peripheral blood of healthy adults following Finnish sauna.
Materials and methods
Twenty healthy unbiased male volunteers (20-30 years old) were exposed to a Finnish sauna bath (3 × 10 min, 90°C). Venous blood samples were drawn before (baseline), immediately, and 6 h as well as 24 h after the sauna bath. Blood analysis included isolation of mononuclear cells, cell staining with mononuclear antibodies, and fluorescence-activated cell sorting (FACS). For baseline and 24 h post-sauna samples colony-forming unit-Hill assays were applied to quantify endothelial progenitor cells (EPC).
Results
Flow cytometry revealed an upregulation of circulating CD45+/CD309+ progenitor cells immediately after the sauna bath, however without reaching statistical significance. Circulating cell numbers of the CD45+CD34+, CD45+CD34+CD133+, and CD45+CD34+CD117+ populations did not show clear enhancements following sauna. EPC colony formation tended to be enhanced after sauna as compared to baseline values.
Conclusion
Peripheral EPC numbers exhibited a moderate increase following Finnish sauna in a cohort of healthy young men. Furthermore, sauna bathing tended to increase EPC colony-forming capacity. These rather weak responses to thermotherapy might indicate a ceiling effect. In individuals exhibiting cardiovascular risk factors the effects may be more pronounced.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
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