Effect of Tocotrienols enriched canola oil on glycemic control and oxidative status in patients with type 2 diabetes mellitus: A randomized double-blind placebo-controlled clinical trial
Vafa M, Haghighat N, Moslehi N, Eghtesadi S, Heydari I
Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 26 citations
How it was studied
- Design
- Randomized controlled trial (classified by our AI screen)
- Studied in
- People
- Main outcome
- Health markers and function
- Intake measured by
- Not stated
Who paid for it
- Funding
- Independent funding
Based on full-text disclosure statement.
Publication
- Published
- 2015-01-01 · J Res Med Sci · vol. 20 · issue 6 · p. 540
- Publisher
- Medknow
- Cited
- 34 citations · more than 83% of similar papers · 1.8× the field average
- References
- 42 works
- Access
- Open access (journal) · CC-BY-NC-SA
- Research areas
- Antioxidant Activity and Oxidative Stress · Coconut Research and Applications · Fatty Acid Research and Health
- Keywords
- Medicine, Canola, Glycemic, Malondialdehyde, Internal medicine, Placebo, Diabetes mellitus, Insulin resistance, Vitamin E, Type 2 diabetes, Type 2 Diabetes Mellitus, Insulin, Endocrinology, Gastroenterology, Oxidative stress, Antioxidant, Food science, Biochemistry, Chemistry
5 authors
From IR
- Mohammadreza VafaIran University of Medical Sciences
- Neda HaghighatAhvaz Jundishapur University of Medical Sciences
- Nazanin MoslehiResearch Institute for Endocrine Sciences; Shahid Beheshti University of Medical Sciences
- Shahriar EghtesadiIran University of Medical Sciences
- Iraj HeydariIran University of Medical Sciences
Abstract
Background
Tocotrienols have been shown to improve glycemic control and redox balance in an animal study, but their effects on patients with diabetes are unknown. The study aimed to investigate whether tocotrienols improves glycemic control, insulin sensitivity, and oxidative stress in individuals with type 2 diabetes mellitus (T2DM).
Materials and methods
This study was a double-blinded, placebo-controlled, randomized trial. A total of 50 patients, aged 35-60 years, with T2DM treated by noninsulin hypoglycemic drugs were randomly assigned to receive either 15 mL/day tocotrienols (200 mg) enriched canola oil (n = 25) or pure canola oil (n = 25) for 8 weeks. Fasting blood sugar (FBS), fasting insulin, total antioxidant capacity (TAC), malondialdehyde (MDA), and homeostatic model assessment for insulin resistance (HOMA-IR) were determined before and after the intervention. The data were compared between and within groups, before and after the intervention.
Results
Baseline characteristics of participants including age, sex, physical activity, disease duration, and type of drug consumption were not significantly different between the two groups. In tocotrienol enriched canola oil, FBS (mean percent change: -15.4% vs. 3.9%; P = 0.006) and MDA (median percent change: -35.6% vs. 16.3%; P = 0.003) were significantly reduced while TAC was significantly increased (median percent change: 21.4% vs. 2.3%; P = 0.001) compared to pure canola oil. At the end of the study, patients who treated with tocotrienols had lower FBS (P = 0.023) and MDA (P = 0.044) compared to the pure canola oil group. However, tocotrienols had no effect on insulin concentrations and HOMA-IR.
Conclusion
Tocotrienols can improve FBS concentrations and modifies redox balance in T2DM patients with poor glycemic control and can be considered in combination with hypoglycemic drugs to better control of T2DM.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY-NC-SA).
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