Association between whole grain intake and stroke risk: evidence from a meta-analysis
Fang L, Li W, Zhang W, Wang Y, Fu S
International journal of clinical and experimental medicine · 10 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Meta-analysis (classified by our AI screen)
- Studied in
- People
- Main outcome
- Clinical events such as disease or death
- Intake measured by
- Not stated
Who paid for it
- Funding
- Funding not disclosed
Publication
- Published
- 2015-01-01 · Int J Clin Exp Med · vol. 8 · issue 9 · pp. 16978–83
- Publisher
- National Institutes of Health
- Cited
- 17 citations · more than 59% of similar papers · 0.6× the field average
- References
- 24 works
- Access
- Paywalled
- Research areas
- Food composition and properties · Nutritional Studies and Diet · Celiac Disease Research and Management
- Keywords
- Medicine, Meta-analysis, Publication bias, Stroke (engine), Confidence interval, Relative risk, Subgroup analysis, Population, Random effects model, Internal medicine, Demography, Environmental health
5 authors
From CN
- Li‐Qun Fang
- Li WenSoochow University; First Affiliated Hospital of Soochow University
- Wenjie Zhang
- Yanan Wang
- Songbin Fu
Abstract
Background
Researches of the relationships between dietary whole grains intake and risk of stroke have produced inconsistent results. We therefore conducted a meta-analysis to summarize the evidence from observed studies regarding the association between whole grain intake and stroke risk.
Methods
Pertinent studies were identified by searching Web of Knowledge and PubMed up to May 2015. Random-effect model was used to combine the relative risk (RR) with the corresponding 95% confidence intervals (CI). Publication bias was estimated using Egger's regression asymmetry test.
Results
Six prospective studies involving 1635 stroke cases and 247487 participants were included in this meta-analysis. Pooled results suggested that highest category of whole grain intake versus lowest category was significantly associated with reduced the risk of stroke [summary RR = 0.86, 95% CI = 0.73-0.99, I2 = 0.0%]. Inverse associations were also found in the America population [summary RR = 0.81, 95% CI = 0.67-0.98, I(2) = 0.0%] and subgroup analysis of females [summary RR = 0.78, 95% CI = 0.63-0.97, I(2) = 0.0%]. No publication bias was found.
Conclusion
Our analysis indicated that higher whole grain intake has a protective effect on stroke.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
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