Effects of creatine monohydrate supplementation on exercise-induced apoptosis in athletes: A randomized, double-blind, and placebo-controlled study
Rahimi R, Mirzaei B, Rahmani-Nia F, Salehi Z
Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 8 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Randomized controlled trial (classified by our AI screen)
- Studied in
- People
- Main outcome
- Mechanisms only
Who paid for it
- Funding
- Independent funding
Based on full-text disclosure statement.
Publication
- Published
- 2015-01-01 · J Res Med Sci · vol. 20 · issue 8 · p. 733
- Publisher
- Medknow
- Cited
- 10 citations · more than 64% of similar papers · 0.6× the field average
- References
- 40 works
- Access
- Open access (journal) · CC-BY-NC-SA
- Research areas
- Muscle metabolism and nutrition · Exercise and Physiological Responses · Thermoregulation and physiological responses
- Keywords
- Medicine, Placebo, Oxidative stress, Athletes, Internal medicine, Creatine, Endocrinology, Creatine Monohydrate, Apoptosis, Placebo-controlled study, Physical therapy, Double blind, Biology, Biochemistry, Pathology
4 authors
From IR
- Rahman RahimiUniversity of Kurdistan
- Bahman MirzaeiUniversity of Guilan
- Farhad Rahmani‐NiaUniversity of Guilan
- Zivar SalehiUniversity of Guilan
Abstract
Background
Creatine monohydrate (CrM) has been shown to be beneficial to health due to its antioxidant potential. Strenuous exercise is associated with oxidative stress, which could lead to apoptosis. We investigated the ability of CrM in amelioration of apoptosis induced by incremental aerobic exercise (AE) to exhaustion in young athletes.
Materials and methods
In a placebo-controlled, double-blind, randomized, parallel study, 31 young athletes (age 19.52 ± 2.75 years, body mass 79.24 ± 16.13 kg, height 1.73 ± 6.49 m, body fat 16.37% ± 5.92%) were randomly assigned to CrM (4 × 5 g/day, n = 15) or placebo (PL: 4 × 5 g/day of maltodextrine powder; n = 16) to investigate the effect of 7 days CrM on serum p53 and insulin-like growth factor-1 (IGF-1) concentration after acute incremental AE test to exhaustion. Subjects performed AE before (test 1) and after 7 days of supplementation (test 2).
Results
Before supplementation, AE to exhaustion induced a significant increase in serum p53 and IGF-1 concentrations at both CrM and PL groups (P 0.05).
Conclusion
Our results suggest that supplementation with CrM prevents apoptosis, as measured by decreases in p53 concentration, induced by AE to exhaustion in young athletes. However, CrM had no effect on IGF-1 concentration after AE to exhaustion in young athletes.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY-NC-SA).
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