Ashwagandha attenuates TNF-α- and LPS-induced NF-κB activation and CCL2 and CCL5 gene expression in NRK-52E cells
Grunz-Borgmann E, Mossine V, Fritsche K, Parrish AR
BMC complementary and alternative medicine · 18 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- In vitro/mechanistic study (classified by our AI screen)
- Studied in
- Cells or lab samples
- Main outcome
- Mechanisms only
Who paid for it
- Funding
- Independent funding
- Government
- Office of Dietary Supplements
- Government
- National Institutes of Health
- Government
- National Institute on Aging
- Government
- National Cancer Institute
- Government
- National Center for Complementary and Alternative Medicine
- Government
- National Center for Complementary and Integrative Health
- Government
- NIA NIH HHS
- Government
- NCCIH NIH HHS
- Grants
- National Center for Complementary and Alternative Medicine (P50 AT006723); National Institute on Aging (R01 AG-034154); National Institute on Aging (RO1AG034154); National Center for Complementary and Integrative Health (P50 AT006723); National Institutes of Health (RO1AG034154)
Based on 8 listed funder(s).
Publication
- Published
- 2015-12-01 · BMC Complement Altern Med · vol. 15 · issue 1 · p. 434
- Publisher
- BioMed Central
- Cited
- 28 citations · more than 95% of similar papers · 5.7× the field average
- Impact
- Top 10% most cited in its field
- References
- 59 works
- Access
- Open access (journal) · CC-BY
- Research areas
- Phytochemicals and Medicinal Plants · Cell death mechanisms and regulation · Humic Substances and Bio-Organic Studies
- Keywords
- CCL5, CCL2, Tumor necrosis factor alpha, Medicine, Chemokine, Lipopolysaccharide, Inflammation, Pharmacology, NF-κB, Cancer research, Immunology, Immune system, T cell
- MeSH
- cell line, humans, sambucus, lipopolysaccharides, tumor necrosis factor-alpha, nf-kappa b, plant extracts, drug evaluation, preclinical, gene expression regulation, chemokine ccl2, chemokine ccl5, transcriptional activation
4 authors
From US
- Elizabeth A. Grunz‐BorgmannUniversity of Missouri Hospital
- Valeri V. MossineUniversity of Missouri
- Kevin L. FritscheUniversity of Missouri
- Alan R. Parrish · correspondingUniversity of Missouri Hospital
Abstract
Background
The aging kidney is marked by a chronic inflammation, which may exacerbate the progression of renal dysfunction, as well as increase the susceptibility to acute injury. The identification of strategies to alleviate inflammation may have translational impact to attenuate kidney disease.
Methods
We tested the potential of ashwaganda, sutherlandia and elderberry on tumor necrosis factor-α (TNF-α) and lipopolysaccharide (LPS) induced chemokine (CCL2 and CCL5) expression in vitro.
Results
Elderberry water-soluble extract (WSE) was pro-inflammatory, while sutherlandia WSE only partially attenuated the TNF-α-induced changes in CCL5. However, ashwaganda WSE completely prevented TNF-α-induced increases in CCL5, while attenuating the increase in CCL2 expression and NF-κB activation. The same pattern of ashwagandha protection was seen using LPS as the pro-inflammatory stimuli.
Conclusions
Taken together, these results demonstrate the ashwaganda WSE as a valid candidate for evaluation of therapeutic potential for the treatment of chronic renal dysfunction.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
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