Serum Levels of 25-Hydroxyvitamin D and Time to Natural Pregnancy
Somigliana E, Paffoni A, Lattuada D, Colciaghi B, Filippi F, La Vecchia I, Tirelli A, Baffero GM, Persico N, Viganò P, Bolis G, Fedele L
Gynecologic and obstetric investigation · 16 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Case-control study (indexed by PubMed)
- Studied in
- People
- Main outcome
- Clinical events such as disease or death
Who paid for it
- Funding
- Funding not disclosed
Publication
- Published
- 2016-01-01 · Gynecol Obstet Invest · vol. 81 · issue 5 · pp. 468–471
- Publisher
- Karger Publishers
- Cited
- 24 citations · more than 88% of similar papers · 2.5× the field average
- References
- 24 works
- Access
- Open access (repository copy) · OTHER-OA
- Research areas
- Vitamin D Research Studies · Cancer Risks and Factors · Vitamin C and Antioxidants Research
- Keywords
- Medicine, Pregnancy, Vitamin D and neurology, Prospective cohort study, Overweight, Internal medicine, vitamin D deficiency, Vitamin, Endocrinology, Gynecology, Obesity, Biology
- MeSH
- humans, vitamin d, case-control studies, fertility, pregnancy, pregnancy trimester, first, adult, female
12 authors
From IT
- Edgardo SomiglianaFondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico
- Alessio PaffoniFondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico
- Debora LattuadaFondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico
- Barbara ColciaghiFondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico
- Francesca FilippiFondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico
- Irene La VecchiaFondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico
Abstract
Aim
The aim of this study was to evaluate whether natural fertility is related to serum 25-hydroxyvitamin D (25-OH-vitamin D) levels.
Methods
A nested case-control study was designed from a prospective cohort of pregnant women undergoing first trimester screening for aneuploidies. Cases included women seeking pregnancy for 12-24 months. Controls were the subsequent age-matched women conceiving in less than 1 year. We excluded women aged ≥40 or <18 years, those assuming supplementary products that included vitamin D before or during pregnancy, those with irregular menstrual cycles or known causes of subfertility, those conceiving through assisted reproductive techniques or requiring ovarian stimulation and those who were overweight or obese. A quantitative detection of serum 25-OH-vitamin D and patients' interview were performed.
Results
Seventy-three cases and 73 matched controls were selected. The mean ± SD serum 25-OH-vitamin D was 21.2 ± 6.8 and 19.7 ± 7.3 ng/ml, respectively (p = 0.16). The number (%) of women with serum levels <20 ng/ml (vitamin D insufficiency) was 34 (47%) and 37 (51%), respectively (p = 0.73). The adjusted OR of longer time to pregnancy in women with vitamin D insufficiency was 0.84 (95% CI 0.42-1.66).
Conclusions
Our study does not support a crucial role of 25-OH-vitamin D in natural fertility.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
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